Department of Social Medicine, Public Health, Graduate School of Medicine,Osaka University,Osaka,Japan.
Department of Public Health, Faculty of Medicine,Hokkaido University,Sapporo,Japan.
Br J Nutr. 2019 Jun;121(12):1357-1364. doi: 10.1017/S000711451900062X. Epub 2019 Mar 20.
Recent studies have shown that micronutrients are involved in the pathology of type 2 diabetes. Antioxidant effects of vitamins C and B2 and homocysteine-lowering effects of vitamins B6, folate and B12 may have protective roles. However, a few reports have investigated the association between dietary water-soluble vitamin intakes and risk of diabetes. In a prospective study encompassing 19 168 healthy Japanese men and women aged 40-79 years, we examined the associations between dietary intakes of water-soluble vitamins, determined by a validated self-administered FFQ, with the risk of 5-year cumulative incidence of type 2 diabetes by using the logistic regression model. Within the 5-year period, there were 494 self-reported new cases of diabetes. Higher dietary intakes of vitamins C, B2 and folate were associated with lower risk of incident diabetes only in women, whereas no associations of dietary intakes of vitamins B1, B3, B5, B6 and B12 were observed in either sex. The multivariable OR in the highest v. the lowest quartile of intakes among women were 0·61 (95 % CI 0·44, 0·94; P-trend = 0·04) for vitamin C, 0·56 (95 % CI 0·34, 0·93; P-trend = 0·03) for vitamin B2 and 0·70 (95 % CI 0·46, 0·98; P-trend = 0·03) for folate. Other than that for sex (P 0·10. In conclusion, higher dietary intakes of vitamins C, B2 and folate, but not other water-soluble vitamins, were associated with reduced risk of type 2 diabetes in Japanese women.
最近的研究表明，微量营养素参与了 2 型糖尿病的病理过程。维生素 C 和 B2 的抗氧化作用以及维生素 B6、叶酸和 B12 的降低同型半胱氨酸作用可能具有保护作用。然而，一些研究报告调查了水溶性维生素的饮食摄入量与糖尿病风险之间的关系。在一项包括 19168 名年龄在 40-79 岁的健康日本男女的前瞻性研究中，我们通过使用逻辑回归模型，检查了由经过验证的自我管理的 FFQ 确定的水溶性维生素的饮食摄入量与 5 年累计 2 型糖尿病发病风险之间的关系。在 5 年内，有 494 例自我报告的新发病例。仅在女性中，较高的维生素 C、B2 和叶酸饮食摄入量与较低的糖尿病发病风险相关，而在两性中均未观察到维生素 B1、B3、B5、B6 和 B12 的饮食摄入量与糖尿病发病风险之间存在关联。在女性中，最高与最低四分位数摄入量之间的多变量 OR 分别为：维生素 C 为 0.61（95%CI 为 0.44，0.94；P 趋势=0.04），维生素 B2 为 0.56（95%CI 为 0.34，0.93；P 趋势=0.03），叶酸为 0.70（95%CI 为 0.46，0.98；P 趋势=0.03）。除性别因素外（P=0.10）。综上所述，较高的维生素 C、B2 和叶酸的饮食摄入量，但不是其他水溶性维生素，与日本女性 2 型糖尿病的发病风险降低有关。
