Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA.
Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA.
Cell Stem Cell. 2018 Mar 1;22(3):325-339. doi: 10.1016/j.stem.2018.01.014. Epub 2018 Feb 8.
Stem cells and tissue-derived stromal cells stimulate the repair of degenerated and injured tissues, motivating a growing number of cell-based interventions in the musculoskeletal field. Recent investigations have indicated that these cells are critical for their trophic and immunomodulatory role in controlling endogenous cells. This Review presents recent clinical advances where stem cells and stromal cells have been used to stimulate musculoskeletal tissue repair, including delivery strategies to improve cell viability and retention. Emerging bioengineering strategies are highlighted, particularly toward the development of biomaterials for capturing aspects of the native tissue environment, altering the healing niche, and recruiting endogenous cells.
干细胞和组织来源的基质细胞刺激退化和损伤组织的修复，这促使越来越多的基于细胞的干预措施应用于肌肉骨骼领域。最近的研究表明，这些细胞对于它们在控制内源性细胞中的营养和免疫调节作用至关重要。本综述介绍了干细胞和基质细胞在刺激肌肉骨骼组织修复方面的最新临床进展，包括改善细胞活力和保留的输送策略。突出了新兴的生物工程策略，特别是开发用于捕获天然组织环境的生物材料，改变愈合小生境和招募内源性细胞的策略。
