Marquardt Laura M, Heilshorn Sarah C
Department of Materials Science and Engineering, Stanford University, Stanford, CA 94305.
Curr Stem Cell Rep. 2016 Sep;2(3):207-220. doi: 10.1007/s40778-016-0058-0. Epub 2016 Jul 1.
Stem cell-based therapies are steadily gaining traction for regenerative medicine approaches to treating disease and injury throughout the body. While a significant body of work has shown success in preclinical studies, results often fail to translate in clinical settings. One potential cause is the massive transplanted cell death that occurs post injection, preventing functional integration with host tissue. Therefore, current research is focusing on developing injectable hydrogel materials to protect cells during delivery and to stimulate endogenous regeneration through interactions of transplanted cells and host tissue. This review explores the design of targeted injectable hydrogel systems for improving the therapeutic potential of stem cells across a variety of tissue engineering applications with a focus on hydrogel materials that have progressed to the stage of preclinical testing.
基于干细胞的疗法在用于治疗全身疾病和损伤的再生医学方法中越来越受到关注。虽然大量研究工作已在临床前研究中取得成功，但结果往往无法转化到临床环境中。一个潜在原因是注射后发生大量移植细胞死亡，阻碍了与宿主组织的功能整合。因此，当前的研究重点是开发可注射水凝胶材料，以在递送过程中保护细胞，并通过移植细胞与宿主组织的相互作用刺激内源性再生。本综述探讨了靶向可注射水凝胶系统的设计，以提高干细胞在各种组织工程应用中的治疗潜力，重点关注已进入临床前测试阶段的水凝胶材料。
