“溶解鸡尾酒”对大鼠脑血流和氧消耗的影响。
Influence of "lytic cocktail" on blood flow and oxygen consumption in the rat brain.
作者信息
Berntman L, Carlsson C
出版信息
Acta Anaesthesiol Scand. 1978;22(5):515-8. doi: 10.1111/j.1399-6576.1978.tb01332.x.
Abstract
The influence of a sedative dose of "lytic cocktail" (chlorpromazine, promethazine and pethidine) on cerebral blood flow (CBF) and oxygen consumjtion (CMRO2) was tested in artificially ventilated rats, maintained on either 70% N2 or 70% N2O. When given alone, the lytic cocktail had no significant effect on CBF or CMRO2. However, in the presence of nitrous oxide there was a 25% reduction in blood flow and oxygen consumption.
摘要
在以70%氮气或70%氧化亚氮维持呼吸的人工通气大鼠中，测试了镇静剂量的“溶积混合液”（氯丙嗪、异丙嗪和哌替啶）对脑血流量（CBF）和氧耗量（CMRO2）的影响。单独使用时，溶积混合液对CBF或CMRO2无显著影响。然而，在氧化亚氮存在的情况下，血流量和氧耗量降低了25%。
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