Carlsson C, Rehncrona S
Acta Anaesthesiol Scand. 1979 Jun;23(3):259-66. doi: 10.1111/j.1399-6576.1979.tb01449.x.
The influence of an anaesthetic dose of chlormethiazole (Hemineurin) on blood flow (CBF) and oxygen consumption (CMRO2) in the rat brain was investigated. In spontaneously breathing animals a dose of 160 mg . kg-1 of chlormethiazole, infused i.v., induced a state close to surgical anaesthesia. In paralyzed animals, the same dose decreased CBF and CMRO2 to about 60% of control, an effect similar to that observed after an anaesthetic dose of phenobarbitone. Neither a protective nor a detrimental effect of chlormethiazole could be demonstrated when the drug was given during reversible and pronounced, incomplete ischaemia, as evaluated from the postischaemic tissue concentrations of labile phosphates (PCr, ATP, ADP, AMP) and of lactate and pyruvate. It is concluded that protection in this situation (as earlier shown with phenobarbitone) must, at least partly, be related to other mechanisms than a depression of metabolism.
研究了麻醉剂量的氯美噻唑（氯美噻唑）对大鼠脑血流量（CBF）和氧耗量（CMRO2）的影响。在自主呼吸的动物中，静脉注射160mg·kg-1的氯美噻唑可诱导出接近手术麻醉的状态。在麻痹动物中，相同剂量可使CBF和CMRO2降至对照值的约60%，这一效果与麻醉剂量的苯巴比妥后观察到的效果相似。从缺血后组织中不稳定磷酸盐（PCr、ATP、ADP、AMP）以及乳酸和丙酮酸的浓度评估，当在可逆且明显的不完全缺血期间给予该药物时，未显示出氯美噻唑的保护作用或有害作用。得出的结论是，在这种情况下的保护作用（如先前用苯巴比妥所显示的）至少部分必须与代谢抑制以外的其他机制有关。
