Runa F, Hamalian S, Meade K, Shisgal P, Gray P C, Kelber J A
Department of Biology, California State University, Northridge, CA.
The Salk Institute for Biological Studies, La Jolla, CA.
Curr Mol Biol Rep. 2017 Dec;3(4):218-229. doi: 10.1007/s40610-017-0073-7. Epub 2017 Oct 30.
The tumor microenvironment (TME) has been recognized as an integral component of malignancies in breast and prostate tissues, contributing in confounding ways to tumor progression, metastasis, therapy resistance and disease recurrence. Major components of the TME are immune cells, fibroblasts, pericytes, endothelial cells, mesenchymal stroma/stem cells (MSCs), and extracellular matrix (ECM) components. Herein, we discuss the molecular and cellular heterogeneity within the TME and how this presents unique challenges and opportunities for treating breast and prostate cancers.
肿瘤微环境（TME）已被公认为乳腺和前列腺组织恶性肿瘤的一个组成部分，以复杂的方式促进肿瘤进展、转移、治疗抵抗和疾病复发。TME的主要成分包括免疫细胞、成纤维细胞、周细胞、内皮细胞、间充质基质/干细胞（MSC）和细胞外基质（ECM）成分。在此，我们讨论TME内的分子和细胞异质性，以及这如何给乳腺癌和前列腺癌的治疗带来独特的挑战和机遇。
