Abbosh Philip H, Plimack Elizabeth R
Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA, USA.
Department of Urology, Einstein Medical Center, Philadelphia, PA, USA.
Bladder Cancer. 2018 Jan 20;4(1):9-18. doi: 10.3233/BLC-170129.
DNA damage response and repair genes (DDR genes) are commonly mutated in bladder cancer. The biological impact of these mutations is an area of intense basic, translational, and clinical interest. As next generation sequencing increases its foothold in the treatment of localized and advanced bladder cancer, the role of DDR genes will continue to evolve. We review the inventory and biology of DDR genes in bladder cancer and describe known and candidate roles for loss of DDR genes to engender therapeutic susceptibilities to various anti-cancer agents.
DNA损伤反应与修复基因（DDR基因）在膀胱癌中普遍发生突变。这些突变的生物学影响是基础、转化和临床研究的热点领域。随着下一代测序技术在局部和晚期膀胱癌治疗中的应用不断增加，DDR基因的作用将持续演变。我们综述了膀胱癌中DDR基因的概况和生物学特性，并描述了DDR基因缺失在导致对各种抗癌药物产生治疗敏感性方面已知的和潜在的作用。
