外周血 MAGE-A 基因表达可作为肺癌患者预后不良的标志物。
MAGE-A gene expression in peripheral blood serves as a poor prognostic marker for patients with lung cancer.
机构信息
Research Center, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Tumor Research Institute, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
出版信息
Thorac Cancer. 2018 Apr;9(4):431-438. doi: 10.1111/1759-7714.12571. Epub 2018 Feb 12.
BACKGROUND
MAGE-A genes belong to the cancer/testis antigens family. The prognostic significance of MAGE-A expression in the peripheral blood of patients with lung cancer is unknown. Therefore, this study evaluated the expression and possible prognostic significance of MAGE-A in the peripheral blood of patients with lung cancer.
METHODS
In this study, we detected MAGE-A gene expression in the peripheral blood of 150 patients with lung cancer and 30 healthy donors using multiplex semi-nested PCR and analyzed their correlation with clinicopathological risk factors.
RESULTS
MAGE-A expression was associated with factors indicating poor prognosis. The expression of MAGE-A and each individual MAGE-A gene were also associated with low overall survival in patients with lung cancer.
CONCLUSION
The expression of MAGE-A genes in peripheral blood may act as a poor prognostic marker in patients with lung cancer.
背景
MAGE-A 基因属于癌症/睾丸抗原家族。MAGE-A 在肺癌患者外周血中的表达的预后意义尚不清楚。因此，本研究评估了 MAGE-A 在肺癌患者外周血中的表达及其可能的预后意义。
方法
本研究采用多重半巢式 PCR 检测 150 例肺癌患者和 30 例健康供者外周血中 MAGE-A 基因的表达，并分析其与临床病理危险因素的相关性。
结果
MAGE-A 表达与提示预后不良的因素相关。MAGE-A 的表达及各单个 MAGE-A 基因的表达与肺癌患者的总生存率降低相关。
结论
外周血中 MAGE-A 基因的表达可能是肺癌患者的不良预后标志物。
Zotero 插件