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黑色素相关抗原-A（MAGE-A）基因表达在多种人类癌症中的预后价值：7428 例患者和 44 项研究的系统评价和荟萃分析。

Prognostic Value of Melanoma-Associated Antigen-A (MAGE-A) Gene Expression in Various Human Cancers: A Systematic Review and Meta-analysis of 7428 Patients and 44 Studies.

机构信息

Department of Cell and Molecular Biology, Manipal School of Life Sciences, Manipal Academy of Higher Education (MAHE), Manipal, Karnataka, 576104, India.

出版信息

Mol Diagn Ther. 2020 Oct;24(5):537-555. doi: 10.1007/s40291-020-00476-5.

DOI:10.1007/s40291-020-00476-5
PMID:32548799
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7497308/
Abstract

BACKGROUND

Members of the melanoma-associated antigen-A (MAGE-A) subfamily are overexpressed in many cancers and can drive cancer progression, metastasis, and therapeutic recurrence.

OBJECTIVE

This study is the first comprehensive meta-analysis evaluating the prognostic utility of MAGE-A members in different cancers.

METHODS

A systematic literature search was conducted in PubMed, Google Scholar, Science Direct, and Web of Science. The pooled hazard ratios with 95% confidence intervals were estimated to evaluate the prognostic significance of MAGE-A expression in various cancers.

RESULTS

In total, 44 eligible studies consisting of 7428 patients from 11 countries were analysed. Univariate and multivariate analysis for overall survival, progression-free survival, and disease-free survival showed a significant association between high MAGE-A expression and various cancers (P < 0.00001). Additionally, subgroup analysis demonstrated that high MAGE-A expression was significantly associated with poor prognosis for lung, gastrointestinal, breast, and ovarian cancer in both univariate and multivariate analysis for overall survival.

CONCLUSION

Overexpression of MAGE-A subfamily members is linked to poor prognosis in multiple cancers. Therefore, it could serve as a potential prognostic marker of poor prognosis in cancers.

摘要

背景

黑色素瘤相关抗原-A（MAGE-A）亚家族成员在许多癌症中过度表达，可驱动癌症进展、转移和治疗复发。

目的

本研究是首次全面的荟萃分析，评估了 MAGE-A 成员在不同癌症中的预后作用。

方法

在 PubMed、Google Scholar、Science Direct 和 Web of Science 中进行了系统的文献检索。通过合并风险比及其 95%置信区间来评估 MAGE-A 表达在各种癌症中的预后意义。

结果

共分析了来自 11 个国家的 44 项符合条件的研究，包含 7428 名患者。单因素和多因素分析总生存期、无进展生存期和无病生存期显示，MAGE-A 高表达与多种癌症显著相关（P<0.00001）。此外，亚组分析表明，在单因素和多因素分析总生存期时，MAGE-A 高表达与肺癌、胃肠道癌、乳腺癌和卵巢癌的预后不良显著相关。

结论

MAGE-A 亚家族成员的过表达与多种癌症的不良预后相关。因此，它可以作为癌症预后不良的潜在预后标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cac7/7497308/1071695ea55d/40291_2020_476_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cac7/7497308/ad00567cc2f9/40291_2020_476_Fig1_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cac7/7497308/e2e0294c3581/40291_2020_476_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cac7/7497308/cdd34269142c/40291_2020_476_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cac7/7497308/11c254cd840b/40291_2020_476_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cac7/7497308/1071695ea55d/40291_2020_476_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cac7/7497308/ad00567cc2f9/40291_2020_476_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cac7/7497308/857b2d9c40fe/40291_2020_476_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cac7/7497308/e9c191c804c0/40291_2020_476_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cac7/7497308/e2e0294c3581/40291_2020_476_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cac7/7497308/cdd34269142c/40291_2020_476_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cac7/7497308/11c254cd840b/40291_2020_476_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cac7/7497308/1071695ea55d/40291_2020_476_Fig7_HTML.jpg

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