Olsson P
Acta Otolaryngol. 1986 Jul-Aug;102(1-2):106-12. doi: 10.3109/00016488609108653.
Measurements of blood flow in the human nasal mucosa can be performed with 133Xe washout technique and with laser doppler flowmetry. These methods are based on different principles and a comparison of the methods is of interest. For this purpose the 133Xe washout and laser doppler techniques were used to evaluate the effect of topical xylometazoline and noradrenaline on blood flow. Xylometazoline was found to induce a dose-dependent decrease in nasal mucosal blood flow, as registered with both methods. After noradrenaline, no change in blood flow was seen in 133Xe washout measurements, whereas a reduced blood flow was registered with laser doppler flowmetry. It is concluded that the 133Xe washout technique and laser doppler flowmetry reflect blood flow in different parts of the vascular bed in the human nasal mucosa, which means that they complement each other in such investigations.
人体鼻黏膜血流测量可采用¹³³氙洗脱技术和激光多普勒血流仪进行。这些方法基于不同原理，对它们进行比较很有意义。为此，采用¹³³氙洗脱技术和激光多普勒技术评估局部用赛洛唑啉和去甲肾上腺素对血流的影响。结果发现，两种方法均显示赛洛唑啉可引起鼻黏膜血流呈剂量依赖性减少。使用去甲肾上腺素后，¹³³氙洗脱测量中未见血流变化，而激光多普勒血流仪测量显示血流减少。得出的结论是，¹³³氙洗脱技术和激光多普勒血流仪反映了人体鼻黏膜血管床不同部位的血流情况，这意味着它们在这类研究中相互补充。
