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2017 年中国感染流感 A(H7N9)病毒幸存者 1 年后的抗体反应。

Influenza A(H7N9) Virus Antibody Responses in Survivors 1 Year after Infection, China, 2017.

出版信息

Emerg Infect Dis. 2018 Apr;24(4):663-672. doi: 10.3201/eid2404.171995. Epub 2018 Apr 17.

DOI:10.3201/eid2404.171995
PMID:29432091
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5875250/
Abstract

Avian influenza A(H7N9) virus has caused 5 epidemic waves in China since its emergence in 2013. We investigated the dynamic changes of antibody response to this virus over 1 year postinfection in 25 patients in Suzhou City, Jiangsu Province, China, who had laboratory-confirmed infections during the fifth epidemic wave, October 1, 2016-February 14, 2017. Most survivors had relatively robust antibody responses that decreased but remained detectable at 1 year. Antibody response was variable; several survivors had low or undetectable antibody titers. Hemagglutination inhibition titer was >1:40 for <40% of the survivors. Measured in vitro in infected mice, hemagglutination inhibition titer predicted serum protective ability. Our findings provide a helpful serologic guideline for identifying subclinical infections and for developing effective vaccines and therapeutics to counter H7N9 virus infections.

摘要

自 2013 年出现以来，甲型流感病毒 H7N9 已在中国引发了 5 次疫情。我们调查了 2016 年 10 月 1 日至 2017 年 2 月 14 日期间，江苏省苏州市第五次疫情期间经实验室确诊的 25 例感染患者在感染后 1 年对该病毒的抗体反应的动态变化。大多数幸存者具有相对较强的抗体反应，尽管在 1 年内有所下降，但仍可检测到。抗体反应存在差异；一些幸存者的抗体滴度较低或无法检测到。幸存者中不到 40%的人的血凝抑制滴度>1:40。在感染的小鼠中进行的体外测量表明，血凝抑制滴度可预测血清的保护能力。我们的研究结果为识别亚临床感染以及开发有效疫苗和治疗方法来对抗 H7N9 病毒感染提供了有帮助的血清学指导。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab06/5875250/f8bd5ce49994/17-1995-F3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab06/5875250/6f99a62f9ffe/17-1995-F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab06/5875250/e0f4fb3d703c/17-1995-F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab06/5875250/f8bd5ce49994/17-1995-F3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab06/5875250/6f99a62f9ffe/17-1995-F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab06/5875250/e0f4fb3d703c/17-1995-F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab06/5875250/f8bd5ce49994/17-1995-F3.jpg

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