Roberts G W, Colter N, Lofthouse R, Bogerts B, Zech M, Crow T J
Biol Psychiatry. 1986 Sep;21(11):1043-50. doi: 10.1016/0006-3223(86)90285-4.
Increased gliosis has been previously described in schizophrenic brain. In this study, the degree of gliosis in schizophrenic and control brains was assessed quantitatively using an antibody to glial fibrillary acidic protein, immunocytochemical techniques, and a computed image analysis system. Twenty separate brain areas were assessed, and no significant differences were found between the schizophrenic and control groups. It seems unlikely that a specific pattern of pathologically significant gliosis is present in schizophrenic brains. These negative findings are of note because of previously reported structural differences in the temporal lobe in the schizophrenic group in this series.
先前已有研究报道精神分裂症患者大脑中胶质细胞增生增加。在本研究中，使用针对胶质纤维酸性蛋白的抗体、免疫细胞化学技术以及计算机图像分析系统，对精神分裂症患者和对照者大脑中的胶质细胞增生程度进行了定量评估。对20个不同的脑区进行了评估，结果发现精神分裂症组和对照组之间没有显著差异。精神分裂症患者大脑中似乎不太可能存在具有病理意义的特定胶质细胞增生模式。鉴于该系列研究中先前报道的精神分裂症组颞叶存在结构差异，这些阴性结果值得关注。
