Roberts G W, Colter N, Lofthouse R, Johnstone E C, Crow T J
Division of Psychiatry, Clinical Research Centre, Harrow, Middlesex, United Kingdom.
Biol Psychiatry. 1987 Dec;22(12):1459-68. doi: 10.1016/0006-3223(87)90104-1.
Recent studies have described two indicators of pathology in the schizophrenic brain--gliosis and atrophy. The degree of gliosis in the temporal lobe of groups of schizophrenics (with demonstrable atrophy), affectives, and controls was quantified using immunocytochemical techniques and computer-assisted densitometry. Twenty areas within the temporal lobe were assessed. Our data showed no evidence of increased gliosis in the schizophrenic group compared to controls and affectives. This extends and replicates our previous findings, demonstrating that the atrophy/aplasia in schizophrenia is not associated with pathologically significant gliosis. Our observations are consistent with other studies, suggesting that the structural change in schizophrenic brains is due to an embryonic insult or developmental anomaly of an, as yet, undetermined nature.
最近的研究描述了精神分裂症大脑病理学的两个指标——神经胶质增生和萎缩。利用免疫细胞化学技术和计算机辅助密度测定法，对精神分裂症患者组（有明显萎缩）、情感障碍患者组和对照组颞叶的神经胶质增生程度进行了量化。对颞叶内的20个区域进行了评估。我们的数据显示，与对照组和情感障碍患者组相比，精神分裂症患者组没有神经胶质增生增加的迹象。这扩展并重复了我们之前的研究结果，表明精神分裂症中的萎缩/发育不全与具有病理意义的神经胶质增生无关。我们的观察结果与其他研究一致，表明精神分裂症大脑的结构变化是由于尚未确定性质的胚胎损伤或发育异常所致。
