Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia.
Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia.
Food Res Int. 2018 Mar;105:517-536. doi: 10.1016/j.foodres.2017.11.023. Epub 2017 Nov 21.
Atherosclerosis is a complex pathology that involves several factors in its development, like oxidative stress, inflammation, hyperlipidemia, platelet aggregation and thrombus formation. Several drugs and therapeutic approaches have been developed to handle these aspects of atherosclerosis. However, some of these treatments can be costly and have undesirable side effects. Many constituents of mushrooms have been shown to have potential anti-atherosclerotic effects in several in vitro and in vivo studies. Recently, the possible mechanisms in which they exert these effects have also been elucidated. In this review, some of the research focusing on mushrooms and their potential anti-atherosclerotic effects are examined. Many mushroom species exhibited anti-oxidative, anti-inflammatory and hypolipidemic effects that can potentially attenuate the progression of atherosclerosis, either through their isolated compounds or use of crude extracts. More studies are focused on the effect that mushrooms have on gene expressions that are involved in oxidative stress, inflammation, and hyperlipidemia. These studies could provide us with a better understanding on the mechanisms in which the consumption of mushrooms could exert their possible anti-atherosclerotic effects. Further research needs to be done to uncover other possible mechanisms that are affected by mushroom use.
动脉粥样硬化是一种复杂的病理学，其发展涉及多个因素，如氧化应激、炎症、高脂血症、血小板聚集和血栓形成。已经开发出几种药物和治疗方法来处理动脉粥样硬化的这些方面。然而，其中一些治疗方法可能成本高昂且有不良副作用。多项体外和体内研究表明，许多蘑菇成分具有潜在的抗动脉粥样硬化作用。最近，也阐明了它们发挥这些作用的可能机制。在这篇综述中，检查了一些专注于蘑菇及其潜在抗动脉粥样硬化作用的研究。许多蘑菇品种表现出抗氧化、抗炎和降血脂作用，通过其分离化合物或使用粗提取物，可能减轻动脉粥样硬化的进展。更多的研究集中在蘑菇对参与氧化应激、炎症和高脂血症的基因表达的影响上。这些研究可以让我们更好地理解蘑菇的摄入如何发挥其可能的抗动脉粥样硬化作用的机制。需要进一步研究以揭示蘑菇使用影响的其他可能机制。
