Hassani Faezeh Vahdati, Shirani Kobra, Hosseinzadeh Hossein
Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Pharmaceutical Research Center, Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Naunyn Schmiedebergs Arch Pharmacol. 2016 Sep;389(9):931-49. doi: 10.1007/s00210-016-1256-0. Epub 2016 May 13.
Metabolic syndrome is defined by a constellation of complex coexisting cardiometabolic risk factors such as hyperglycemia, dyslipidemia, inflammation, abdominal obesity, coagulopathies, and hypertension that raise the risk of diabetes mellitus and cardiovascular disease. Recently, there has been an increasing interest in the use of herbs and natural compounds in prevention and treatment of diseases and a large number of published articles have focused on this issue. Rosmarinus officinalis L. or rosemary (Lamiaceae) is a rich source of phenolic phytochemicals having significant anti-oxidant, anti-inflammatory, hypoglycemic, hypolipidemic, hypotensive, anti-atherosclerotic, anti-thrombotic, hepatoprotective, and hypocholesterolemic effects. The purpose of this review is to highlight the interesting pharmacological effects of rosemary, and its active compounds, and the related mechanisms in the management of metabolic syndrome that are documented in in vitro and in vivo studies.
代谢综合征由一系列复杂并存的心脏代谢危险因素所定义，如高血糖、血脂异常、炎症、腹型肥胖、凝血功能障碍和高血压，这些因素会增加患糖尿病和心血管疾病的风险。最近，人们对使用草药和天然化合物预防和治疗疾病的兴趣日益浓厚，大量已发表的文章都聚焦于这个问题。迷迭香叶或迷迭香（唇形科）富含酚类植物化学物质，具有显著的抗氧化、抗炎、降血糖、降血脂、降压、抗动脉粥样硬化、抗血栓形成、保肝和降胆固醇作用。本综述的目的是强调迷迭香及其活性化合物有趣的药理作用，以及体外和体内研究中记录的其在代谢综合征管理中的相关机制。
