Department of Pathological Anatomy, Hospital Complex of Jaén, Avenida del Ejército Español, 10, Jaén 23007, Spain.
Department of Biochemistry and Molecular Biology II, Faculty of Pharmacy, University of Granada, University campus of Cartuja, Granada 18071, Spain; Institute of Nutrition and Food Technology José Mataix, University of Granada, Biomedical Research Centre, Avenida del Conocimiento, Armilla, Granada 18016, Spain.
Food Res Int. 2018 Mar;105:654-667. doi: 10.1016/j.foodres.2017.11.053. Epub 2017 Nov 21.
Many beneficial properties have been attributed to the Mediterranean diet. Over the years, researchers have attempted to learn which foods and which food components are responsible for good health. One of these components is hydroxytyrosol, an important phenolic compound present in olive oil. Hydroxytyrosol is a molecule of high interest to the pharmaceutical industry due to its anti-inflammatory and antimicrobial qualities its role against cardiovascular diseases and metabolic syndrome and for its neuroprotection, antitumour, and chemo modulation effects. The interest in this molecule has led to wide research on its biological activities, its beneficial effects in humans and how to synthetize new molecules from hydroxytyrosol. This review describes the vast range of information about hydroxytyrosol, focusing on its involvement in biological mechanisms and modulation effects on different pathologies. This review also serves to highlight the role of hydroxytyrosol as a nutraceutical and as a potential therapeutic agent.
许多有益的特性都归因于地中海饮食。多年来，研究人员一直试图了解哪些食物和食物成分对健康有益。其中一种成分是羟基酪醇，它是橄榄油中一种重要的酚类化合物。由于羟基酪醇具有抗炎和抗菌特性，能够预防心血管疾病和代谢综合征，并且具有神经保护、抗肿瘤和化疗调节作用，因此它是制药行业非常感兴趣的一种分子。对这种分子的兴趣促使人们广泛研究其生物学活性、它在人类中的有益作用以及如何从羟基酪醇合成新分子。本文综述了关于羟基酪醇的大量信息，重点介绍了它在不同病理机制中的作用和调节作用。本文还强调了羟基酪醇作为一种营养保健品和潜在治疗剂的作用。
