a Molecular Biology Research Center, Key Medical Health Laboratory for Laboratory Medicine of Shandong Province, Department of Laboratory Medicine , Shandong Medical College , Linyi , Shandong , China.
Immunopharmacol Immunotoxicol. 2018 Jun;40(3):187-192. doi: 10.1080/08923973.2018.1434792. Epub 2018 Feb 12.
The aim of this paper is to clarify the critical role of GPCR signaling in T cell immunity.
The G protein-coupled receptors (GPCRs) are the most common targets in current pharmaceutical industry, and represent the largest and most versatile family of cell surface communicating molecules. GPCRs can be activated by a diverse array of ligands including neurotransmitters, chemokines as well as sensory stimuli. Therefore, GPCRs are involved in many key cellular and physiological processes, such as sense of light, taste and smell, neurotransmission, metabolism, endocrine and exocrine secretion. In recent years, GPCRs have been found to play an important role in immune system. T cell is an important type of immune cell, which plays a central role in cell-mediated immunity. A variety of GPCRs and their signaling mediators (RGS proteins, GRKs and β-arrestin) have been found to express in T cells and involved T cell-mediated immunity. We will summarize the role of GPCR signaling and their regulatory molecules in T cell activation, homeostasis and function in this article.
GPCR signaling plays an important role in T cell activation, homeostasis and function.
GPCR signaling is critical in regulating T cell immunity.
本文旨在阐明 G 蛋白偶联受体（GPCR）信号在 T 细胞免疫中的关键作用。
G 蛋白偶联受体（GPCRs）是当前制药行业最常见的靶点，也是细胞表面通讯分子中最大、最多样化的家族。GPCR 可被多种配体激活，包括神经递质、趋化因子以及感觉刺激等。因此，GPCR 参与许多关键的细胞和生理过程，如光感、味觉和嗅觉、神经传递、代谢、内分泌和外分泌分泌。近年来，GPCR 被发现在免疫系统中发挥重要作用。T 细胞是一种重要的免疫细胞，在细胞介导的免疫中起着核心作用。已发现多种 GPCR 及其信号转导介质（RGS 蛋白、GRK 和β-arrestin）在 T 细胞中表达，并参与 T 细胞介导的免疫。本文将总结 GPCR 信号及其调节分子在 T 细胞激活、稳态和功能中的作用。
GPCR 信号在 T 细胞激活、稳态和功能中发挥重要作用。
GPCR 信号在调节 T 细胞免疫中至关重要。
