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富氢盐水对压力超负荷诱导的大鼠心肌肥大的保护作用：JAK-STAT信号通路的潜在作用

Protective effect of hydrogen-rich saline on pressure overload-induced cardiac hypertrophyin rats: possible role of JAK-STAT signaling.

作者信息

Fan Zhixin, Gao Yufei, Huang Zhiwei, Xue Fenghua, Wu Shujing, Yang Jing, Zhu Liqun, Fu Lu

机构信息

Department of Cardiovascular Medicine, First Affiliated Hospital of Harbin Medical University, 23 Youzheng Street, Nangang District, Harbin, Heilongjiang, 150001, China.

Emergency Department, Heilongjiang Provincial Hospital, Harbin, China.

出版信息

BMC Cardiovasc Disord. 2018 Feb 13;18(1):32. doi: 10.1186/s12872-018-0773-9.

DOI:10.1186/s12872-018-0773-9
PMID:29433438
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5810059/
Abstract

BACKGROUND

Molecular hydrogen has been shown to have antioxidant effect and have been used to prevent oxidative stress-related diseases. The goal of this study was to explore if hydrogen-rich saline (HRS) plays a cardioprotective effect on abdominal aortic constriction (AAC) induced cardiac hypertrophy in rats. 60adult Sprague-Dawley rats received surgically the AAC for 6-week. After the surgery, the rats were randomly divided into 4 groups (15 for each):1: sham-operated (sham); 2: AAC-model; 3: AAC + Low HRS (LHRS); and 4: AAC + High HRS (HHRS). The rats in sham and AAC-model groups were treated with normal saline intraperitoneally, while rats in LHRS and HHRS groups were intraperitoneally treated with 3 or 6 mL/kg HRS daily, respectively, for 6-week.

RESULTS

The ratios of HW/BW and LVW/BW were shown in an order of Model > LHRS > HHRS > SHAM groups. The cardiac hypertrophy was also manifested with increased expressions of atrial natriuretic peptide (ANP), brain natriuretic peptides (BNP) and fibrosis of cardiac tissues in AAC-model group, which could likewise be restrained in LHRS and HHRS groups. Moreover, the JAK-STAT (Janus Kinase-Signal transducers and activators of transcription) signaling molecule expressions were decreased with HRS treatment.

CONCLUSIONS

Our results showed a protective effect of HRS on pressure overload-induced cardiac hypertrophy in rats, which may be associated to a decreasing in JAK-STAT signaling pathway.

摘要

背景

分子氢已被证明具有抗氧化作用，并已用于预防与氧化应激相关的疾病。本研究的目的是探讨富氢盐水（HRS）对大鼠腹主动脉缩窄（AAC）诱导的心脏肥大是否具有心脏保护作用。60只成年Sprague-Dawley大鼠接受了为期6周的AAC手术。手术后，将大鼠随机分为4组（每组15只）：1：假手术组（sham）；2：AAC模型组；3：AAC + 低剂量HRS组（LHRS）；4：AAC + 高剂量HRS组（HHRS）。假手术组和AAC模型组大鼠腹腔注射生理盐水，而LHRS组和HHRS组大鼠分别每天腹腔注射3或6 mL/kg HRS，持续6周。

结果

HW/BW和LVW/BW的比值呈现出模型组> LHRS组> HHRS组>假手术组的顺序。心脏肥大还表现为AAC模型组中心房利钠肽（ANP）、脑利钠肽（BNP）表达增加以及心脏组织纤维化，而LHRS组和HHRS组同样可以抑制这些变化。此外，HRS治疗可降低JAK-STAT（Janus激酶-信号转导子和转录激活子）信号分子的表达。

结论

我们的结果表明，HRS对大鼠压力超负荷诱导的心脏肥大具有保护作用，这可能与JAK-STAT信号通路的降低有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0367/5810059/25d7516f0543/12872_2018_773_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0367/5810059/7fc63464bf8d/12872_2018_773_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0367/5810059/202eee83a29f/12872_2018_773_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0367/5810059/62c24cd8f9f3/12872_2018_773_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0367/5810059/d3a5b721b9a8/12872_2018_773_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0367/5810059/4e698c8a07bc/12872_2018_773_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0367/5810059/25d7516f0543/12872_2018_773_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0367/5810059/7fc63464bf8d/12872_2018_773_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0367/5810059/202eee83a29f/12872_2018_773_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0367/5810059/62c24cd8f9f3/12872_2018_773_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0367/5810059/d3a5b721b9a8/12872_2018_773_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0367/5810059/4e698c8a07bc/12872_2018_773_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0367/5810059/25d7516f0543/12872_2018_773_Fig6_HTML.jpg

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