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孕妇正常和异常阴道菌群中的阴道乳杆菌谱。

Vaginal lactobacilli profile in pregnant women with normal & abnormal vaginal flora.

机构信息

Department of Microbiology & Immunology, ICMR-National Institute of Nutrition, Hyderabad, India.

出版信息

Indian J Med Res. 2017 Oct;146(4):534-540. doi: 10.4103/ijmr.IJMR_774_16.

DOI:10.4103/ijmr.IJMR_774_16
PMID:29434069
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5819037/
Abstract

BACKGROUND & OBJECTIVES: Lactobacilli species that are better adapted to vaginal environment of women may colonize better and offer protection against vaginal pathogenic bacteria. In this study, the distribution of common Lactobacillus species was investigated in pregnant women.

METHODS

Sixty seven pregnant women were included in the study and vaginal samples were collected for Gram staining. Women were classified as normal vaginal flora, intermediate flora and bacterial vaginosis (BV) based on Nugent's score. Vaginal samples were also collected for the identification of Lactobacillus spp. by multiplex polymerase chain reaction (PCR) profiling of 16S rDNA amplification method.

RESULTS

Lactobacillus crispatus (100%) was the most predominant Lactobacillus spp. present in pregnant women with normal flora, followed by L. iners (77%), L. jensenii (74%) and L. helveticus (60%). While, L. iners was commonly present across groups in women with normal, intermediate or BV flora, L. crispatus, L. jensenii and L. helveticus decreased significantly as the vaginal flora changed to intermediate and BV. In women with BV, except L. iners other species of lactobacilli was less frequently prevalent. Species such as L. rhamnosus, L. fermentum, L. paracasei and L. casei were not detected in any vaginal sample.

INTERPRETATION & CONCLUSIONS: L. crispatus, L. jensinii and L. helveticus were predominant species in women with normal flora. L. crispatus alone or in combination with L. jensinii and L. helveticus may be evaluated for probiotic properties for the prevention and treatment of BV.

摘要

背景与目的

更适应女性阴道环境的乳杆菌物种可能会更好地定植，并提供针对阴道致病菌的保护。本研究调查了孕妇常见乳杆菌物种的分布。

方法

纳入 67 名孕妇进行研究，并采集阴道标本进行革兰氏染色。根据 Nugent 评分，将女性分为正常阴道菌群、中间菌群和细菌性阴道病（BV）。还通过 16S rDNA 扩增的多重聚合酶链反应（PCR）分析收集阴道样本以鉴定乳杆菌 spp。

结果

在正常菌群的孕妇中，最主要的乳杆菌 spp 是 L. crispatus（100%），其次是 L. iners（77%）、L. jensenii（74%）和 L. helveticus（60%）。而 L. iners 常见于正常、中间或 BV 菌群的女性中，L. crispatus、L. jensenii 和 L. helveticus 随着阴道菌群向中间和 BV 变化而显著减少。在 BV 女性中，除了 L. iners 外，其他乳杆菌物种的流行频率较低。在任何阴道样本中均未检测到 L. rhamnosus、L. fermentum、L. paracasei 和 L. casei 等物种。

解释与结论

L. crispatus、L. jensinii 和 L. helveticus 是正常菌群女性中的主要物种。L. crispatus 单独或与 L. jensinii 和 L. helveticus 联合使用可能会被评估为预防和治疗 BV 的益生菌特性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3b3/5819037/587e119e61d9/IJMR-146-534-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3b3/5819037/cf2bb14a4919/IJMR-146-534-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3b3/5819037/587e119e61d9/IJMR-146-534-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3b3/5819037/cf2bb14a4919/IJMR-146-534-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3b3/5819037/587e119e61d9/IJMR-146-534-g004.jpg

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