Institute of Applied Mathematics, Interdisciplinary Center of Scientific Computing and BIOQUANT Center, Heidelberg University, Im Neuenheimer Feld 205, 69120, Heidelberg, Germany.
Department of Medicine V, Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.
Sci Rep. 2018 Feb 12;8(1):2809. doi: 10.1038/s41598-018-21115-4.
Acute myeloid leukemia (AML) is a heterogeneous disease. One reason for the heterogeneity may originate from inter-individual differences in the responses of leukemic cells to endogenous cytokines. On the basis of mathematical modeling, computer simulations and patient data, we have provided evidence that cytokine-independent leukemic cell proliferation may be linked to early relapses and poor overall survival. Depending whether the model of cytokine-dependent or cytokine-independent leukemic cell proliferation fits to the clinical data, patients can be assigned to two groups that differ significantly with respect to overall survival. The modeling approach further enables us to identify parameter constellations that can explain unexpected responses of some patients to external cytokines such as blast crisis or remission without chemotherapy.
急性髓系白血病（AML）是一种异质性疾病。这种异质性的一个原因可能源于白血病细胞对内源性细胞因子反应的个体间差异。基于数学建模、计算机模拟和患者数据，我们已经提供了证据，表明细胞因子非依赖性白血病细胞增殖可能与早期复发和总体生存率差有关。根据细胞因子依赖性或非依赖性白血病细胞增殖模型是否符合临床数据，可以将患者分为两组，这两组在总体生存率方面有显著差异。该建模方法还使我们能够确定参数组合，这些参数组合可以解释某些患者对外部细胞因子（如急变期或无化疗缓解）的意外反应。
