Matalliotaki Charoula, Matalliotakis Michail, Ieromonachou Panagiotis, Goulielmos George N, Zervou Maria I, Laliotis Aggelos, Spandidos Demetrios A, Arici Aydin, Matalliotakis Ioannis
Department of Obstetrics and Gynecology, Venizeleio General Hospital, 71409 Heraklion, Crete, Greece.
Department of Histopathology, Venizeleio General Hospital, 71409 Heraklion, Crete, Greece.
Oncol Lett. 2018 Feb;15(2):1529-1532. doi: 10.3892/ol.2017.7449. Epub 2017 Nov 20.
The purpose of this study was two-fold, first to investigate the association between endometriosis and the risk of benign gynecologic tumors and, secondly, to evaluate the distribution of endometrioma and ovarian cysts in women with endometriosis. The medical and pathological reports of 1,000 women with endometriosis were retrospectively reviewed. The incidence of ovarian cysts, uterine leiomyomas and adenomyosis, as well as the side of ovarian cysts were further compared. A total of 295 cases of endometriomas, 172 cases of adenomyosis, 173 cases of ovarian cysts and 89 cases of uterine leiomyomas were confirmed histologically in patients with endometriosis. Serous cysts represented the most frequent diagnosis (n=81, 8.1%) in women with ovarian cysts, followed by dermoid cysts (n=15, 1.2%). In women with unilateral endometriomas, the observed proportion of left-sided cysts was found in 65.6% (164 of 250), significantly higher compared with right-sided cysts (86 out of 250, 34.4%) (P<0.001). Moreover, patients with other ovarian cysts were recognized as left-sided in 60% (96 out of 160) of cases, significantly higher compared with right-sided cysts (64 out of 160, 40%) (P<0.01). On the whole, the current study indicates that endometriosis may be associated with an increased risk of benign gynecological tumors, such as ovarian cysts, adenomyosis and leiomyomas. The results of this study confirm a left lateral predisposition of endometriomas and ovarian cysts.
本研究的目的有两个，一是调查子宫内膜异位症与良性妇科肿瘤风险之间的关联，二是评估子宫内膜异位症女性中子宫内膜瘤和卵巢囊肿的分布情况。回顾性分析了1000例子宫内膜异位症女性的医学和病理报告。进一步比较了卵巢囊肿、子宫平滑肌瘤和子宫腺肌病的发病率以及卵巢囊肿的发生侧别。经组织学确诊，子宫内膜异位症患者中共有295例子宫内膜瘤、172例子宫腺肌病、173例卵巢囊肿和89例子宫平滑肌瘤。浆液性囊肿是卵巢囊肿女性中最常见的诊断类型（n = 81，8.1%），其次是皮样囊肿（n = 15，1.2%）。在单侧子宫内膜瘤女性中，左侧囊肿的观察比例为65.6%（250例中的164例），显著高于右侧囊肿（250例中的86例，34.4%）（P < 0.001）。此外，其他卵巢囊肿患者中60%（160例中的96例）被认定为左侧囊肿，显著高于右侧囊肿（160例中的64例，40%）（P < 0.01）。总体而言，当前研究表明子宫内膜异位症可能与卵巢囊肿、子宫腺肌病和平滑肌瘤等良性妇科肿瘤风险增加有关。本研究结果证实了子宫内膜瘤和卵巢囊肿的左侧倾向。
