Hu Bing, Guo Yu, Zou Xiaoqiang, Dong Jing, Pan Long, Yu Min, Yang Zhejia, Zhou Chaowei, Cheng Zhang, Tang Wanyue, Sun Haochen
Institute of Applied Mathematics, Department of Mathematics and Statistics, College of Science, Huazhong Agricultural University, Wuhan, 430070 China.
Cogn Neurodyn. 2018 Feb;12(1):103-119. doi: 10.1007/s11571-017-9457-x. Epub 2017 Oct 20.
Based on a classical model of the basal ganglia thalamocortical network, in this paper, we employed a type of the deep brain stimulus voltage on the subthalamic nucleus to study the control mechanism of absence epilepsy seizures. We found that the seizure can be well controlled by turning the period and the duration of current stimulation into suitable ranges. It is the very interesting bidirectional periodic adjustment phenomenon. These parameters are easily regulated in clinical practice, therefore, the results obtained in this paper may further help us to understand the treatment mechanism of the epilepsy seizure.
基于基底神经节丘脑皮质网络的经典模型，本文采用一种作用于丘脑底核的深部脑刺激电压来研究失神癫痫发作的控制机制。我们发现，通过将电流刺激的周期和持续时间调整到合适的范围，可以很好地控制癫痫发作。这是非常有趣的双向周期性调节现象。这些参数在临床实践中易于调节，因此，本文获得的结果可能会进一步帮助我们理解癫痫发作的治疗机制。
