School of Science, Beijing University of Posts and Telecommunications, Beijing 100876, China.
State Key Laboratory of Networking and Switching Technology, Beijing University of Posts and Telecommunications, Beijing 100876, China.
Neural Plast. 2021 Mar 13;2021:6640105. doi: 10.1155/2021/6640105. eCollection 2021.
Low-frequency oscillatory activity (3-9 Hz) and increased synchrony in the basal ganglia (BG) are recognized to be crucial for Parkinsonian tremor. However, the dynamical mechanism underlying the tremor-related oscillations still remains unknown. In this paper, the roles of the indirect and hyperdirect pathways on synchronization and tremor-related oscillations are considered based on a modified Hodgkin-Huxley model. Firstly, the effects of indirect and hyperdirect pathways are analysed individually, which show that increased striatal activity to the globus pallidus external (GPe) or strong cortical gamma input to the subthalamic nucleus (STN) is sufficient to promote synchrony and tremor-related oscillations in the BG network. Then, the mutual effects of both pathways are analysed by adjusting the related currents simultaneously. Our results suggest that synchrony and tremor-related oscillations would be strengthened if the current of these two paths are in relative imbalance. And the network tends to be less synchronized and less tremulous when the frequency of cortical input is in the theta band. These findings may provide novel treatments in the cortex and striatum to alleviate symptoms of tremor in Parkinson's disease.
低频振荡活动（3-9 Hz）和基底神经节（BG）中的同步增加被认为是帕金森震颤的关键。然而，震颤相关振荡的动力学机制仍不清楚。在本文中，基于改进的 Hodgkin-Huxley 模型，考虑了间接和直接通路对同步和震颤相关振荡的作用。首先，单独分析间接和直接通路的作用，结果表明增加苍白球外部（GPe）的纹状体活性或强烈的皮质γ输入到丘脑底核（STN）足以促进 BG 网络中的同步和震颤相关振荡。然后，通过同时调整相关电流来分析两条通路的相互作用。我们的结果表明，如果这两条路径的电流存在相对不平衡，同步和震颤相关的振荡将会增强。而当皮质输入的频率处于 theta 波段时，网络的同步性和震颤性都会降低。这些发现可能为减轻帕金森病震颤症状提供在皮层和纹状体的新治疗方法。
