Key Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, School of Chemistry and Chemical Engineering, Xi'an 710119, China.
Biomater Sci. 2018 Feb 27;6(3):462-472. doi: 10.1039/c7bm01124e.
With the development of nanotechnology, functional amyloid materials are drawing increasing attention, and numerous remarkable applications are emerging. Amyloids, defined as a class of supramolecular assemblies of misfolded proteins or peptides into β-sheet fibrils, have evolved in many new respects and offer abundant chemical/biological functions. These proteinaceous micro/nano-structures provide excellent biocompatibility, rich phase behaviours, strong mechanical properties, and stability at interfaces not only in nature but also in functional materials, displaying versatile interactions with surfaces/interfaces that have been widely adopted in bioadhesion, synthetic biology, and composites. Overall, functional amyloids at surfaces/interfaces have excellent potential applications in next-generation biotechnology and biomaterials.
随着纳米技术的发展，功能性淀粉样物质越来越受到关注，许多引人注目的应用也应运而生。淀粉样物质被定义为一类由错误折叠的蛋白质或肽组成的超分子组装体，形成β-折叠纤维，在许多新方面得到了发展，并提供了丰富的化学/生物学功能。这些蛋白质微/纳米结构不仅在自然界中，而且在功能材料中都具有极好的生物相容性、丰富的相行为、强大的机械性能和界面稳定性，与表面/界面的多种相互作用已被广泛应用于生物黏附、合成生物学和复合材料。总的来说，表面/界面的功能性淀粉样物质在下一代生物技术和生物材料中有很好的应用潜力。
