Tau Positron Emission Tomography in Autosomal Dominant Alzheimer Disease: Small Windows, Big Picture.
作者信息
McDade Eric, Bateman Randall J
机构信息
Dominantly Inherited Alzheimer Network Trials Unit, Department of Neurology, Washington University School of Medicine, St Louis, Missouri.
出版信息
JAMA Neurol. 2018 May 1;75(5):536-538. doi: 10.1001/jamaneurol.2017.4026.
Abstract
摘要
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Tau and amyloid β proteins distinctively associate to functional network changes in the aging brain.tau 和淀粉样β蛋白分别与衰老大脑的功能网络变化有关。
Alzheimers Dement. 2017 Nov;13(11):1261-1269. doi: 10.1016/j.jalz.2017.02.011. Epub 2017 Mar 30.
2
Phases of Hyperconnectivity and Hypoconnectivity in the Default Mode and Salience Networks Track with Amyloid and Tau in Clinically Normal Individuals.在临床正常个体中，默认模式网络和突显网络的高连接性和低连接性阶段与淀粉样蛋白和tau蛋白相关。
J Neurosci. 2017 Apr 19;37(16):4323-4331. doi: 10.1523/JNEUROSCI.3263-16.2017. Epub 2017 Mar 17.
3
Relationships between flortaucipir PET tau binding and amyloid burden, clinical diagnosis, age and cognition.氟替卡匹尔PET tau蛋白结合与淀粉样蛋白负荷、临床诊断、年龄和认知之间的关系。
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Temporal T807 binding correlates with CSF tau and phospho-tau in normal elderly.在正常老年人中，颞叶T807结合与脑脊液中的tau蛋白和磷酸化tau蛋白相关。
Neurology. 2016 Aug 30;87(9):920-6. doi: 10.1212/WNL.0000000000003050. Epub 2016 Jul 29.
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Evaluation of Tau Imaging in Staging Alzheimer Disease and Revealing Interactions Between β-Amyloid and Tauopathy.评估 Tau 成像在阿尔茨海默病分期中的作用及揭示β-淀粉样蛋白与 Tau 病之间的相互作用。
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Tau and Aβ imaging, CSF measures, and cognition in Alzheimer's disease.阿尔茨海默病中的tau蛋白和淀粉样β蛋白成像、脑脊液检测及认知情况
Sci Transl Med. 2016 May 11;8(338):338ra66. doi: 10.1126/scitranslmed.aaf2362.
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Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer's disease.Tau正电子发射断层扫描（PET）模式反映了阿尔茨海默病的临床和神经解剖学变异性。
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8
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PART, a distinct tauopathy, different from classical sporadic Alzheimer disease.PART，一种独特的tau蛋白病，与经典的散发性阿尔茨海默病不同。
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