Gonoodi Kayhan, Moslem Alireza, Darroudi Susan, Ahmadnezhad Mahsa, Mazloum Zahra, Tayefi Maryam, Zadeh Seyed Amir Tabatabaei, Eslami Saeid, Shafiee Mojtaba, Khashayarmanesh Zahra, Haghighi Hamideh Moalemzadeh, Ferns Gordon A, Ghayour-Mobarhan Majid
Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Anesthesiology, Sabzevar University of Medical Sciences, Sabzevar, Iran.
Clin Biochem. 2018 Apr;54:25-31. doi: 10.1016/j.clinbiochem.2018.02.006. Epub 2018 Feb 10.
Girls with micronutrient deficiencies may have impaired growth and development, and furthermore this may also impact on their childbearing. We have investigated the relationship between serum zinc and copper concentrations, dietary zinc and copper intake and anthropometric and demographic parameters, and cardiovascular risk factors, in 408 girls living in northeastern Iran.
A total of 408 healthy girls, aged 12-18 years old, were included in our study. Serum zinc and copper concentrations were measured by flame atomic absorption (Varian AA240FS) and zinc and copper intake were assessed using a 3-day dietary record.
There was a weak correlation between serum and dietary zinc intake (r = 0.117, p = 0.018). The correlation between serum and dietary copper approached significance (r = -0.094, p = 0.056). The mean serum zinc and copper concentrations were 14.61 ± 2.71 μmol/L and 19.48 ± 8.01 μmol/L respectively. Height, total cholesterol (TC) and low-density lipoprotein (LDL) were positively correlated with serum copper concentration. Subjects with high serum copper concentrations (>24 μmol/L) were found to have a significantly higher fasting blood glucose (FBG) compared to subjects with normal, or low serum copper concentrations (p = 0.033). Girls who were in the 5th percentile or greater for height were found to have higher serum copper concentrations than girls in other height categories.
There was a weak relationship between dietary and serum concentrations of zinc. Copper status was associated with anthropometric and biochemical parameters, including FBG and lipid profile. Further studies are required to define the role of copper in metabolic health.
患有微量营养素缺乏症的女孩可能生长发育受损，此外，这也可能影响其生育能力。我们调查了伊朗东北部408名女孩的血清锌和铜浓度、膳食锌和铜摄入量与人体测量和人口统计学参数以及心血管危险因素之间的关系。
本研究共纳入408名12 - 18岁的健康女孩。血清锌和铜浓度通过火焰原子吸收法（瓦里安AA240FS）测定，锌和铜摄入量通过3天饮食记录进行评估。
血清锌摄入量与膳食锌摄入量之间存在弱相关性（r = 0.117，p = 0.018）。血清铜与膳食铜之间的相关性接近显著（r = -0.094，p = 0.056）。血清锌和铜的平均浓度分别为14.61±2.71μmol/L和19.48±8.01μmol/L。身高、总胆固醇（TC）和低密度脂蛋白（LDL）与血清铜浓度呈正相关。与血清铜浓度正常或较低的受试者相比，血清铜浓度高（>24μmol/L）的受试者空腹血糖（FBG）显著更高（p = 0.033）。身高处于第5百分位或更高的女孩血清铜浓度高于其他身高类别的女孩。
膳食锌浓度与血清锌浓度之间存在弱关系。铜状态与人体测量和生化参数有关，包括空腹血糖和血脂谱。需要进一步研究来确定铜在代谢健康中的作用。
