Koo S I, Williams D A
Am J Clin Nutr. 1981 Nov;34(11):2376-81. doi: 10.1093/ajcn/34.11.2376.
The effect of zinc status on the distribution of serum cholesterol among the major serum lipoproteins was assessed in adult male rats fed a zinc-deficient diet (0.37 ppm Zn) as compared with those of pair-fed and ad libitum-fed zinc-supplemented controls (41 ppm Zn). All data were collected within the first 4 wk of dietary treatment before the manifestation of any external symptoms of zinc deficiency. The acute zinc depletion produced a significant reduction in total serum cholesterol; the reduction was primarily due to the selective decline in high-density lipoprotein-cholesterol. Zinc depletion per se produced no significant alterations in very low-density lipoprotein- or low-density lipoprotein-cholesterol level. In addition, linear regression analysis based on the 36 pairs of serum zinc and high-density lipoprotein-cholesterol values showed a significant positive correlation (r = + 0.81; p less than 0.01) between these two parameters. The data also indicated a significant correlation between the ratio of zinc/copper and total serum cholesterol. This relationship was, however, solely dependent upon serum zinc status rather than serum copper. The serum levels of copper were not affected by zinc depletion over the period of 4 wk. These results present new evidence for the close association between the nutritional status of zinc and high-density lipoprotein concentration in adult male rats and draw attention to the potential significance of zinc nutriture in relation to cardiovascular health.
在成年雄性大鼠中，评估了锌状态对主要血清脂蛋白中血清胆固醇分布的影响。将喂食缺锌饮食（锌含量为0.37 ppm）的大鼠与成对喂食和随意进食补锌对照（锌含量为41 ppm）的大鼠进行比较。所有数据均在饮食处理的前4周内收集，此时尚未出现锌缺乏的任何外部症状。急性锌缺乏导致血清总胆固醇显著降低；这种降低主要是由于高密度脂蛋白胆固醇的选择性下降。锌缺乏本身对极低密度脂蛋白或低密度脂蛋白胆固醇水平没有显著影响。此外，基于36对血清锌和高密度脂蛋白胆固醇值的线性回归分析表明，这两个参数之间存在显著正相关（r = + 0.81；p < 0.01）。数据还表明锌/铜比值与血清总胆固醇之间存在显著相关性。然而，这种关系仅取决于血清锌状态，而非血清铜。在4周的时间里，血清铜水平不受锌缺乏的影响。这些结果为成年雄性大鼠锌营养状况与高密度脂蛋白浓度之间的密切关联提供了新证据，并提请注意锌营养与心血管健康相关的潜在重要性。
