Victorino R M, Lucas M, de Moura M C
J Clin Lab Immunol. 1986 Jul;20(3):137-41.
A percentage of human T lymphocytes forms rosettes with autologous erythrocytes and this property has been considered as a marker for post-thymic precursor suppressor cells capable of providing suppression under the influence of inducer cells. We quantitated autologous rosette-forming T cells (ARFC) in the peripheral blood of 37 patients with chronic HBV infection: 8 healthy carriers, 9 chronic persistent hepatitis (CPH-B) and 20 chronic active hepatitis (CAH-B). Two control groups were studied, one consisting of 26 healthy individuals and the other of 8 individuals with non-HBV-associated CAH. Patients with non-HBV-associated CAH had a significant reduction in the proportion of ARFC, whereas CAH-B patients fell into 2 distinct patterns, one with increased and the other with decreased proportions of ARFC. This was unrelated to the degree of biochemical activity of the disease or to degree of viral replication as defined by HBeAg status and HBV-DNA in the serum. Healthy carriers and CPH-B had no changes in ARFC. Simultaneous quantitation of OKT4 and OKT8+ cells was done and a positive correlation was found between the proportions of ARFC and the proportions of OKT8+ cells. The possible significance of this correlation and the relevance of the bimodal distribution of autologous rosette-forming cells in CAH-B are discussed.
一定比例的人类T淋巴细胞可与自身红细胞形成玫瑰花结，这一特性被视为胸腺后前体抑制细胞的标志物，该细胞能够在诱导细胞的影响下发挥抑制作用。我们对37例慢性乙肝病毒感染患者外周血中的自身玫瑰花结形成T细胞（ARFC）进行了定量分析，其中包括8例健康携带者、9例慢性持续性肝炎（CPH-B）患者和20例慢性活动性肝炎（CAH-B）患者。研究了两个对照组，一组由26名健康个体组成，另一组由8名非乙肝病毒相关性慢性活动性肝炎患者组成。非乙肝病毒相关性慢性活动性肝炎患者的ARFC比例显著降低，而CAH-B患者则呈现出两种不同的模式，一种ARFC比例增加，另一种ARFC比例降低。这与疾病的生化活动程度或血清中HBeAg状态和乙肝病毒DNA所定义的病毒复制程度无关。健康携带者和CPH-B患者的ARFC无变化。同时对OKT4和OKT8+细胞进行了定量分析，发现ARFC比例与OKT8+细胞比例之间存在正相关。本文讨论了这种相关性的可能意义以及CAH-B中自身玫瑰花结形成细胞双峰分布的相关性。
