Barnaba V, Musca A, Cordova C, Levrero M, Ruocco G, Albertini-Petroni V, Balsano F
Clin Exp Immunol. 1983 Aug;53(2):281-8.
The relationship between T cell subset, as defined by monoclonal antibodies, and suppressor cell function, using a short lived suppressor cell assay, was studied in 38 chronic hepatitis B virus (HBV) carriers and in 32 patients with HBsAg negative chronic active hepatitis (CAH). Patients with HBV chronic infection showed an absolute reduction in the OKT4 positive subset and a significantly decreased OKT4/OKT8 ratio, as compared with healthy controls. Patients with anti-nuclear antibodies (ANA) and anti-smooth muscle antibodies (ASMA) positive CAH with or without antibodies to HBV antigens, namely anti-HBs and anti-HBc, demonstrated a significant reduction in cytotoxic/suppressor T cells and an increased helper/suppressor ratio. A negative correlation between suppressor index (SI) and OKT4/OKT8 ratio (P less than 0.01), and a positive correlation between SI and OKT8 positive cells absolute number (P less than 0.01) were also observed.
运用单克隆抗体定义的T细胞亚群与采用短期抑制细胞检测法检测的抑制细胞功能之间的关系，在38例慢性乙型肝炎病毒（HBV）携带者及32例HBsAg阴性慢性活动性肝炎（CAH）患者中进行了研究。与健康对照相比，HBV慢性感染患者OKT4阳性亚群绝对减少，OKT4/OKT8比值显著降低。抗核抗体（ANA）和抗平滑肌抗体（ASMA）阳性的CAH患者，无论有无HBV抗原抗体（即抗-HBs和抗-HBc），均显示细胞毒性/抑制性T细胞显著减少，辅助/抑制比值增加。还观察到抑制指数（SI）与OKT4/OKT8比值呈负相关（P<0.01），SI与OKT8阳性细胞绝对数呈正相关（P<0.01）。
