Department of Medicinal Chemistry, University of Utah, Salt Lake City, Utah, USA 84112.
Nat Prod Rep. 2018 Apr 25;35(4):357-378. doi: 10.1039/c7np00053g.
Covering: up to 2018 Symbiotic microbes interact with animals, often by producing natural products (specialized metabolites; secondary metabolites) that exert a biological role. A major goal is to determine which microbes produce biologically important compounds, a deceptively challenging task that often rests on correlative results, rather than hypothesis testing. Here, we examine the challenges and successes from the perspective of marine animal-bacterial mutualisms. These animals have historically provided a useful model because of their technical accessibility. By comparing biological systems, we suggest a common framework for establishing chemical interactions between animals and microbes.
截至 2018 年共生微生物与动物相互作用，通常通过产生具有生物作用的天然产物（特殊代谢物；次生代谢物）。一个主要目标是确定哪些微生物产生具有生物学重要性的化合物，这是一项具有欺骗性的挑战性任务，通常依赖于相关性结果，而不是假设检验。在这里，我们从海洋动物-细菌共生关系的角度来探讨这些挑战和成功。这些动物由于其技术上的可及性，历史上一直是一个有用的模型。通过比较生物系统，我们提出了一个用于确定动物和微生物之间化学相互作用的通用框架。
