海绵来源真菌来源的细胞保护型聚酮化合物

Cytoprotective Polyketides from Sponge-Derived Fungus .

机构信息

Nhatrang Institute of Technology Research and Application, Vietnam Academy of Science and Technology, Nha Trang 650000, Vietnam.

G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Science, Prospect 100-Letiya Vladivostoka, 159, Vladivostok 690022, Russia.

出版信息

Molecules. 2022 Nov 7;27(21):7650. doi: 10.3390/molecules27217650.

DOI:10.3390/molecules27217650

PMID:36364472

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9655818/

Abstract

The new polyketides lopouzanones A and B, as well as the new 1--acetyl and 2--acetyl derivatives of dendrodochol B, were isolated from the sponge-derived marine fungus strain 168CLC-57.3. Moreover, six known polyketides, gliorosein, balticolid, dendrodolide G, dihydroisocoumarine, (-)-5-methylmellein, and dendrodochol B, were identified. The structures of the isolated compounds were determined by a combination of NMR and ESIMS techniques. The absolute configurations of the lopouzanones A and B were determined using the Mosher's method. The cytotoxicity of the isolated compounds against human prostate cancer cells PC-3 and normal rat cardiomyocytes H9c2 was investigated. Gliorosein showed weak DPPH radical-scavenging activity and in vitro cardioprotective effects toward rotenone toxicity and CoCl-mimic hypoxia.

摘要

新的聚酮类化合物 lopouzanones A 和 B，以及 dendrodochol B 的 1--乙酰基和 2--乙酰基衍生物，是从海绵来源的海洋真菌 168CLC-57 中分离得到的。此外，还鉴定了六种已知的聚酮类化合物，gliorosein、balticolid、dendrodolide G、二氢异香豆素、(-)-5-甲基麦角甾醇和 dendrodochol B。通过 NMR 和 ESIMS 技术的组合确定了分离化合物的结构。lopouzanones A 和 B 的绝对构型是通过 Mosher 法确定的。对分离得到的化合物对人前列腺癌细胞 PC-3 和正常大鼠心肌细胞 H9c2 的细胞毒性进行了研究。Gliorosein 表现出较弱的 DPPH 自由基清除活性和对鱼藤酮毒性和 CoCl 模拟缺氧的体外心脏保护作用。