Pekonen F, Rasi V, Ammälä M, Viinikka L, Ylikorkala O
Thromb Res. 1986 Sep 1;43(5):553-60. doi: 10.1016/0049-3848(86)90075-7.
Platelet function and coagulation activity were followed prospectively throughout normal pregnancy and in puerperium in 17 healthy women. Plasma beta-thromboglobulin reflecting platelet activation increased progressively during pregnancy. This was not accompanied by any changes in platelet count or lifespan nor in serum or plasma thromboxane B2 levels. The levels of both factor VIII:C and factor VIIIR:Ag increased, the former less than the latter resulting in a rise of the FVIIIR:Ag/FVIII:C ratio. Antithrombin III (AT III), however remained unaltered. FVIIIR:Ag/FVIII:C ratio was increased both in mild (n = 7) and severe (n = 9) preeclampsia, whereas beta-thromboglobulin was increased and AT III was decreased only in severe preeclampsia. Platelet count and lifespan, plasma and serum thromboxane B2 as well as FVIII:C were normal in severe preeclampsia.
对17名健康女性在整个正常孕期及产褥期进行了血小板功能和凝血活性的前瞻性跟踪研究。反映血小板活化的血浆β-血小板球蛋白在孕期逐渐升高。但这并未伴有血小板计数、寿命以及血清或血浆血栓素B2水平的任何变化。因子VIII:C和因子VIIIR:Ag水平均升高，前者升高幅度小于后者，导致FVIIIR:Ag/FVIII:C比值升高。然而，抗凝血酶III（AT III）保持不变。轻度子痫前期（n = 7）和重度子痫前期（n = 9）患者的FVIIIR:Ag/FVIII:C比值均升高，而仅在重度子痫前期患者中，β-血小板球蛋白升高，AT III降低。重度子痫前期患者的血小板计数、寿命、血浆和血清血栓素B2以及FVIII:C均正常。
