Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine and The Whitaker Cardiovascular Institute , Boston, Massachusetts.
Am J Physiol Renal Physiol. 2018 Jul 1;315(1):F1-F6. doi: 10.1152/ajprenal.00594.2017. Epub 2018 Feb 14.
The prevalence of hypertension rises with age to approximately two out of three adults over the age of 60 in the United States. Although the mechanisms underlying age-related hypertension are incompletely understood, sodium homeostasis is critical to the long-term regulation of blood pressure and there is strong evidence that aging is associated with alterations in renal sodium handling. This minireview focuses on recent advancements in our understanding of the vascular, neurohumoral, and renal mechanisms that influence sodium homeostasis and promote age-related hypertension.
在美国，高血压的患病率随着年龄的增长而上升，大约每三个 60 岁以上的成年人中就有两个患有高血压。尽管与年龄相关的高血压的机制尚不完全清楚，但钠平衡对长期血压调节至关重要，并且有强有力的证据表明衰老与肾脏钠处理的改变有关。这篇小综述重点介绍了我们对影响钠平衡并促进与年龄相关的高血压的血管、神经激素和肾脏机制的理解的最新进展。
