Zhang Yajie, Zhang Tingting, Liu Min, Kuang Ye, Zu Guangyue, Zhang Kunchi, Cao Yi, Pei Renjun
CAS Key Laboratory for Nano-Bio Interface, Division of Nanobiomedicine, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou 215123, China.
School of Pharmacy, Xi'an Jiaotong University, Xi'an 710061, China.
J Nanosci Nanotechnol. 2018 Jun 1;18(6):3759-3774. doi: 10.1166/jnn.2018.15226.
Magnetic resonance imaging is a powerful diagnostic technology with high spatial resolution and non-invasion. The contrast agents have significant effect on the resolution of the MR imaging. However, the commercial contrast agents (CAs) usually consist of individual Gd3+ chelated with a low molecular weight acyclic or cyclic ligand, and these small-molecule CAs are usually subjected to nonspecificity, thus leading to rapid renal clearance and modest contrast enhancement for tumor imaging. In recent years, the nanostructured materials conjugated with aptamers were widely used and opened a new door in biomedical imaging due to excellent specificity, non-immunogenicity, easily synthesis and chemical modification of aptamers. This review summarizes all kinds of aptamertargeted MRI CAs and their applications.
磁共振成像（MRI）是一种强大的诊断技术，具有高空间分辨率且无创。造影剂对磁共振成像的分辨率有显著影响。然而，商业造影剂（CAs）通常由与低分子量无环或环状配体螯合的单个Gd3+组成，这些小分子造影剂通常具有非特异性，从而导致快速肾脏清除以及肿瘤成像的对比度增强效果一般。近年来，与适配体缀合的纳米结构材料由于适配体具有优异的特异性、非免疫原性、易于合成和化学修饰等特点而被广泛应用，并为生物医学成像打开了一扇新的大门。本综述总结了各种适配体靶向的MRI造影剂及其应用。
