用于检测阿霉素的与聚二烯丙基二甲基氯化铵复合的锰掺杂硫化锌量子点的增强室温磷光

Enhanced Room-Temperature Phosphorescence of Mn-Doped ZnS Quantum Dots Composited with PDDA for Detection of Adriamycin.

作者信息

Liu Chun-Ling, Hou Chang-Jun, Huo Dan-Qun

机构信息

Chongqing Public Health Medical Center, Chongqing, 400036, P. R. China.

Key Laboratory of Biorheological Science and Technology (Ministry of Education), Chongqing University, Chongqing, 400030, P. R. China.

出版信息

J Nanosci Nanotechnol. 2018 Apr 1;18(4):2993-2999. doi: 10.1166/jnn.2018.14531.

DOI:10.1166/jnn.2018.14531

PMID:29442985

Abstract

In this work, a simple room-temperature phosphorescence (RTP) method was first proposed to detect adriamycin, by using a functional material of Mn doped ZnS quantum dots (Mn-ZnS QDs) composited with poly(diallyldimethylammonium chloride) (PDDA). After PDDA was associated to the Mn-ZnS QDs, the RTP intensity was significantly enhanced. As a result, Mn-ZnS QDs/PDDA nanoassemblies greatly improve the adriamycin detection ability of QDs and provide an important method for developing more effective and sensitive adriamycin detection sensor. The method based upon RTP has a linear range from 0.5 to 64.0 μM with a detection limit (3σ/s) for adriamycin of 0.45 μM. The developed method was further successfully applied to detect adriamycin in human serum samples (diluted 50 times) with satisfactory results, and the recovery ranged from 98.3 to 101.3.

摘要

在这项工作中，首次提出了一种简单的室温磷光（RTP）方法来检测阿霉素，该方法使用了与聚二烯丙基二甲基氯化铵（PDDA）复合的锰掺杂硫化锌量子点（Mn-ZnS QDs）功能材料。PDDA与Mn-ZnS QDs结合后，RTP强度显著增强。结果，Mn-ZnS QDs/PDDA纳米组装体极大地提高了量子点对阿霉素的检测能力，并为开发更有效、更灵敏的阿霉素检测传感器提供了一种重要方法。基于RTP的方法线性范围为0.5至64.0 μM，阿霉素的检测限（3σ/s）为0.45 μM。所开发的方法进一步成功应用于检测人血清样品（稀释50倍）中的阿霉素，结果令人满意，回收率在98.3%至101.3%之间。