Huang Jing, Yu Yiming, Lin Wei, Zhang Dandan, Deng Zaichun, Ding Qunli
Department of Pharmacy, The Affiliated Hospital of Medical School of Ningbo University Department of Respiratory Medicine, The Affiliated Hospital of Medical School of Ningbo University, Ningbo, Zhejiang, China.
Medicine (Baltimore). 2018 Feb;97(7):e9996. doi: 10.1097/MD.0000000000009996.
Eosinophilic pleural effusion (EPE) is an eosinophil count ≥10% in pleural effusion, which is a rare condition in drug therapy.
We describe the case of a 70-year-old Alzheimer patient who was taking olanzapine for 2 months for the treatment of depression, and developed peripheral eosinophilia and bilateral EPE.
Olanzapine-induced peripheral eosinophilia and eosinophilic pleural effusion was diagnosed.
Olanzapine was discontinued, and repeated drainage of fluid from the pleural cavity was performed.
All symptoms-as well as the EPE-were resolved 6 months later.
This case is a reminder that olanzapine may be a potential agent for EPE, and that this should be considered in clinical practice.
嗜酸性粒细胞性胸腔积液（EPE）是指胸腔积液中嗜酸性粒细胞计数≥10%，这在药物治疗中是一种罕见的情况。
我们描述了一名70岁阿尔茨海默病患者的病例，该患者因治疗抑郁症服用奥氮平2个月后出现外周嗜酸性粒细胞增多和双侧EPE。
诊断为奥氮平引起的外周嗜酸性粒细胞增多和嗜酸性粒细胞性胸腔积液。
停用奥氮平，并反复进行胸腔积液引流。
6个月后所有症状以及EPE均得到缓解。
该病例提醒我们奥氮平可能是导致EPE的潜在药物，临床实践中应予以考虑。
