Sakagami Hiroshi, Tomomura Mineko
Meikai University Research Institute of Odontology (M-RIO), 1-1 Keyakidai, Sakado, Saitama 350-0283, Japan.
Division of Biochemistry, Department of Oral Biology & Engineering, Meikai University School of Dentistry, 1-1 Keyakidai, Sakado, Saitama 350-0283, Japan.
Medicines (Basel). 2018 Feb 14;5(1):21. doi: 10.3390/medicines5010021.
This review article summarizes the recent progress in dental applications of natural products. Catechin gel showed selective antimicrobial activity, whereas the alkaline extract of various plant species rich in lignin carbohydrate complex (LCC) showed much higher antiviral activity than lower molecular weight polyphenols. Mouthwash with the alkaline extract of a plant classified as OTC effectively reduced halitosis. Unexpectedly, many polyphenolic compounds purified from the natural kingdom showed much lower tumor-specificity against human oral squamous cell lines as compared with antitumor agents, although they showed apoptosis-inducing activity. The alkaline extract of bamboo leaf, which exerted various common biological activities with LCC, showed osteogenic activity by stimulating differentiation toward osteoblasts while inhibiting differentiation toward osteoclasts. LCC enhanced the dectin-2 mRNA expression in macrophages, whereas glucan showed anti-osteoblastic action via dectin-1. These data suggest that natural products exert their biological activity by interacting with these molecules.
这篇综述文章总结了天然产物在牙科应用方面的最新进展。儿茶素凝胶显示出选择性抗菌活性，而富含木质素碳水化合物复合物（LCC）的各种植物物种的碱性提取物显示出比低分子量多酚更高的抗病毒活性。用一种归类为非处方药的植物的碱性提取物制成的漱口水能有效减少口臭。出乎意料的是，与抗肿瘤药物相比，许多从自然界提纯的多酚类化合物对人类口腔鳞状细胞系的肿瘤特异性要低得多，尽管它们显示出诱导细胞凋亡的活性。竹叶的碱性提取物与LCC具有多种共同的生物学活性，通过刺激向成骨细胞的分化同时抑制向破骨细胞的分化而显示出成骨活性。LCC增强了巨噬细胞中dectin-2 mRNA的表达，而葡聚糖通过dectin-1显示出抗成骨细胞作用。这些数据表明天然产物通过与这些分子相互作用发挥其生物学活性。
