Turnbull Chris D
NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.
Oxford Centre for Respiratory Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
J Thorac Dis. 2018 Jan;10(Suppl 1):S33-S39. doi: 10.21037/jtd.2017.10.33.
Obstructive sleep apnoea (OSA) is a common disorder and is associated with cardiovascular disease. Continuous positive airway pressure (CPAP), whilst reducing blood pressure, has not been shown to reduce cardiovascular events when used as a treatment solely for this purpose in patients with previous cardiovascular disease. Developing a better understanding of the mechanisms underlying cardiovascular disease in OSA is important to develop new treatments. Potential causative mechanisms for cardiovascular disease in OSA include arousal induced sympathetic activation, large intrathoracic pressure swings leading to shear stress on the heart and great vessels, and intermittent hypoxia (IH). This review discusses the role of IH, as a major physiological consequence of OSA, in the development of cardiovascular disease.
阻塞性睡眠呼吸暂停（OSA）是一种常见疾病，与心血管疾病相关。持续气道正压通气（CPAP）虽然能降低血压，但在仅用于治疗既往有心血管疾病的患者时，尚未显示能减少心血管事件。更好地了解OSA中心血管疾病的潜在机制对于开发新的治疗方法很重要。OSA中心血管疾病的潜在致病机制包括觉醒诱导的交感神经激活、导致心脏和大血管剪切应力的巨大胸内压力波动以及间歇性缺氧（IH）。本综述讨论了作为OSA主要生理后果的IH在心血管疾病发生发展中的作用。
