Takano Tomomi, Hiramatsu Kanae, Matsuyama Mifuyu, Mutoh Karin, Matsumoto Yuka, Fukushima Toshifumi, Doki Tomoyoshi, Kusuhara Hajime, Hohdatsu Tsutomu
Laboratory of Veterinary Infectious Disease, School of Veterinary Medicine, Kitasato University, Towada, Aomori, 034-8628, Japan.
Health and Environment Research Institute, Yokkaichi, Mie, Japan.
Arch Virol. 2018 Jun;163(6):1503-1510. doi: 10.1007/s00705-018-3770-5. Epub 2018 Feb 14.
Norovirus (NoV) infection is the most common cause of acute gastroenteritis in humans of all ages worldwide. When cats are experimentally infected with feline norovirus (FNoV), they develop symptoms of acute gastroenteritis. Therefore, FNoV infection may serve as an animal model for the disease caused by human norovirus infection. In this study, we examined whether FNoV of cats infected with genogroup GVI are protected from reinfection with the same strain. The blood anti-FNoV IgG level was inversely correlated with the viral load in stool samples and the clinical score of FNoV-infected cats, but complete prevention of reinfection was not observed. These findings were similar to the results of a reinfection experiment with NoV in human volunteers.
诺如病毒（NoV）感染是全球所有年龄段人类急性胃肠炎最常见的病因。当猫通过实验感染猫诺如病毒（FNoV）时，它们会出现急性胃肠炎症状。因此，FNoV感染可作为人类诺如病毒感染所致疾病的动物模型。在本研究中，我们检测了感染基因群GVI的猫的FNoV是否能免受同一毒株的再次感染。血液中抗FNoV IgG水平与粪便样本中的病毒载量以及FNoV感染猫的临床评分呈负相关，但未观察到再次感染被完全预防。这些发现与人类志愿者中诺如病毒再次感染实验的结果相似。
