School of Veterinary Medicine, Kitasato University, Towada, Aomori, 034-8628, Japan.
Health and Environment Research Institute, Yokkaichi, Mie, 512-1211, Japan.
Arch Virol. 2024 Sep 18;169(10):201. doi: 10.1007/s00705-024-06137-w.
Feline norovirus (FNoV) is a potential pathogen of feline gastroenteritis and has two genogroups (GIV and GVI). Few epidemiological studies have been conducted on FNoV. We designed two enzyme-linked immunosorbent assays (ELISAs) to identify genogroup-specific FNoV antibodies for serological surveillance. Analysis of sera from cats experimentally infected with FNoV GIV or GVI and from specific-pathogen-free (SPF) cats confirmed that the two recombinant proteins used in the assay react in a genogroup-specific manner. Of the 183 samples tested, 6.6% were positive for GIV and 26.2% were positive for GVI. Antibodies to both FNoV genogroups were detected in sera collected in 2005, seven years before FNoV was first reported.
猫诺如病毒（FNoV）是猫胃肠炎的潜在病原体，有两个基因组（GIV 和 GVI）。对 FNoV 的流行病学研究较少。我们设计了两种酶联免疫吸附测定（ELISA）来鉴定针对血清学监测的基因组特异性 FNoV 抗体。分析用 FNoV GIV 或 GVI 感染的实验猫和无特定病原体（SPF）猫的血清证实，用于检测的两种重组蛋白以基因组特异性方式反应。在检测的 183 个样本中，6.6%对 GIV 呈阳性，26.2%对 GVI 呈阳性。在 2005 年采集的血清中检测到了两种 FNoV 基因组的抗体，而 FNoV 是在七年前首次报告的。
