School of Chemistry and Materials Science, Jiangsu Key Laboratory of Green Synthesis for Functional Materials, Jiangsu Normal University, Xuzhou Jiangsu 221116, P. R. China.
Org Biomol Chem. 2018 Mar 7;16(10):1679-1685. doi: 10.1039/c8ob00005k.
CuI functions as a mild Lewis acid catalyst to promote the condensation and cyclization reaction of 2-amino-N-(2-hydroxyphenyl)benzamide and 2-bromobenzaldehyde to build the quinazoline moiety first. With the addition of CsCO, it also can catalyse the subsequent intramolecular Ullmann type reaction to give 16H-dibenzo[2,3:6,7][1,4]oxazepino[5,4-b]quinazolin-16-ones in good yields.
CuI 作为一种温和的路易斯酸催化剂，可促进 2-氨基-N-(2-羟基苯基)苯甲酰胺和 2-溴苯甲醛的缩合和环化反应，首先构建喹唑啉部分。加入 CsCO₃ 后，它还可以催化随后的分子内 Ullmann 型反应，以高产率得到 16H-二苯并[2,3:6,7][1,4]氧氮杂卓[5,4-b]喹唑啉-16-酮。
