Wu Yue, Wang Xiao-Ni, Wang Ningli, Han Ying, Ma Daqing, Lu Yan
a Department of Ophthalmology , Beijing Shijitan Hospital, Capital Medical University , Beijing , China.
b Department of Neurology , Xuan Wu Hospital of Capital Medical University , Beijing , China.
Int J Neurosci. 2018 Sep;128(9):849-853. doi: 10.1080/00207454.2018.1438428. Epub 2018 Feb 22.
Purpose/aim: We investigated the regularity changes of the retinal nerve fiber layer (RNFL) and macular ganglion cell complex (mGCC) of the amnestic mild cognitive impairment (aMCI) patients in this prospective cohort study.
Twenty-four aMCI patients and 30 health controls, who are more than 60 years old, were recruited into the study. The RNFL and the mGCC average thickness were measured with Fourier-domain optical coherence tomography (FD-OCT).
Compared with that in the controls, the intraocular pressure (IOP) was significantly lower in the aMCI patients. A significant decrease in RNFL thickness in superior temporal, temporal upper (TU), and temporal upper and lower (TL) (TU+TL) quadrants was found in the aMCI patients than in the controls. The average thickness of the mGCC was also significantly thinner in the aMCI patients than in the controls.
Retinal degeneration in the aMCI patients detected by OCT together with lower IOP may indicate disease pathological progression.
目的/目标：在这项前瞻性队列研究中，我们调查了遗忘型轻度认知障碍（aMCI）患者视网膜神经纤维层（RNFL）和黄斑神经节细胞复合体（mGCC）的规律性变化。
招募了24名年龄超过60岁的aMCI患者和30名健康对照者参与研究。使用傅里叶域光学相干断层扫描（FD-OCT）测量RNFL和mGCC的平均厚度。
与对照组相比，aMCI患者的眼压（IOP）显著降低。发现aMCI患者颞上、颞上（TU）和颞上下（TL）（TU + TL）象限的RNFL厚度较对照组显著降低。aMCI患者的mGCC平均厚度也明显薄于对照组。
OCT检测到的aMCI患者视网膜变性以及较低的IOP可能表明疾病的病理进展。
