肿瘤脂生成中的化学遗传学。

Chemical genetics in tumor lipogenesis.

机构信息

Department of Pharmacy, Pharmaceutical Biology, Ludwig-Maximilians-University of Munich, Butenandtstr. 5-13, Munich 81377, Germany.

出版信息

Biotechnol Adv. 2018 Nov 1;36(6):1724-1729. doi: 10.1016/j.biotechadv.2018.02.007. Epub 2018 Feb 13.

DOI:10.1016/j.biotechadv.2018.02.007

PMID:29447918

Abstract

Since cancer cells depend on de novo lipogenesis for energy supply, highly active membrane biosynthesis and signaling, enhanced fatty acid synthesis is a crucial characteristic of cancer cells. Hence, targeting lipogenic enzymes and signaling cascades is a very promising approach in developing innovative therapeutic agents for the fight against cancer. This review summarizes main aspects of altered fatty acid synthesis in cancer cells and emphasizes the power of chemical genetic approaches in identifying and analyzing novel anti-cancer drug candidates interfering with lipid metabolism.

摘要

由于癌细胞依赖从头合成途径获取能量供应、进行高效的膜生物合成和信号转导，因此增强脂肪酸合成是癌细胞的一个重要特征。因此，靶向关键的脂代谢酶和信号通路是开发创新抗癌治疗药物的一个极具前景的方法。本文综述了癌细胞中脂肪酸合成改变的主要方面，并强调了化学遗传学方法在鉴定和分析新型干扰脂代谢的抗癌药物候选物方面的强大作用。