Department of Radiotherapy, Policlinico Umberto I, "Sapienza" University of Rome, Rome, Italy.
Department of Oral and Maxillo Facial Sciences, Policlinico Umberto I "Sapienza" University of Rome, Italy.
Neoplasia. 2018 Mar;20(3):227-232. doi: 10.1016/j.neo.2018.01.002. Epub 2018 Feb 12.
In treating head and neck cancer (HNC), the objectives are provided for best functional results and minimal risk of serious complications. The choice of appropriate management depends primarily on specific site and stage of primary tumor at diagnosis. Radiation therapy (RT) with or without concomitant chemotherapy represents a classical treatment option. In this review, we provide an update of recent research strategies to counteract the existing damage caused by RT and highlight clinical trials currently in progress. We discuss the challenges in the evaluation of new stage system and RT-related toxicity onset. We mainly address the deficiencies and the advantages noted in the current treatment era.
在治疗头颈部癌症（HNC）时，目标是提供最佳的功能结果和最小的严重并发症风险。适当的治疗方法的选择主要取决于诊断时原发性肿瘤的特定部位和阶段。放射治疗（RT）联合或不联合化疗是一种经典的治疗选择。在这篇综述中，我们提供了最近对抗 RT 引起的现有损伤的研究策略的更新，并强调了目前正在进行的临床试验。我们讨论了在评估新的分期系统和 RT 相关毒性发生方面的挑战。我们主要讨论了在当前治疗时代注意到的缺陷和优势。
