Abudukelimu Kudelaiti, Tuerxuntayi Ailifeire, Aierken Aikepaer, Keranmu Rexiati, Wufuer Duolikun
Department of Oral and Maxillofacial Surgery, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, China.
Department of Gastroenterology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, China.
Front Oncol. 2025 May 19;15:1543055. doi: 10.3389/fonc.2025.1543055. eCollection 2025.
To investigate the changes of serum carbohydrate antigen 125 (CA125), neuron-specific enolase (NSE), neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and systemic inflammation response index (SIRI) in patients with oral squamous cell carcinoma(OSCC) and their diagnostic value for OSCC.
A retrospective analysis was conducted on 136 patients with oral squamous cell carcinoma (OSCC) and 34 healthy controls. Blood routine parameters, as well as serum levels of CA125 and NSE, were obtained for the patients. Additionally, the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic inflammation response index (SIRI) were calculated. The diagnostic value of each marker, both individually and in combination, was evaluated using receiver operating characteristic (ROC) curve analysis.
We found that the levels of CA125, NSE, NLR, PLR, and SIRI in the oral squamous cell carcinoma group were significantly higher than those in the healthy control group ( <0.001, =0.004, =0.034, =0.035, =0.012). Significant differences were observed in NLR, PLR, and SIRI with respect to the size of the primary tumor and local lymph node involvement, as well as substantial differences in NLR and SIRI with distant metastasis (<0.05). When NLR, PLR, and SIRI were combined with CA125 and NSE, the area under the curve (AUC) significantly increased (<0.05). Further analysis using Delong's test revealed a statistically significant difference in AUC values, suggesting that the combined diagnostic approach was more effective than individual markers.
The diagnostic efficiency of OSCC can be enhanced by combining CA125, NSE, NLR, PLR, and SIRI. This combined approach offers high sensitivity and specificity for early diagnosis.
探讨口腔鳞状细胞癌（OSCC）患者血清糖类抗原125（CA125）、神经元特异性烯醇化酶（NSE）、中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）及全身炎症反应指数（SIRI）的变化及其对OSCC的诊断价值。
对136例口腔鳞状细胞癌患者和34例健康对照者进行回顾性分析。检测患者血常规参数以及血清CA125和NSE水平。此外，计算中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）及全身炎症反应指数（SIRI）。采用受试者工作特征（ROC）曲线分析评估各标志物单独及联合检测的诊断价值。
我们发现口腔鳞状细胞癌组的CA125、NSE、NLR、PLR和SIRI水平显著高于健康对照组（<0.001，=0.004，=0.034，=0.035，=0.012）。观察到NLR、PLR和SIRI在原发肿瘤大小和局部淋巴结受累方面存在显著差异，在远处转移方面NLR和SIRI也存在显著差异（<0.05）。当NLR、PLR和SIRI与CA125和NSE联合检测时，曲线下面积（AUC）显著增加（<0.05）。使用德龙检验进行进一步分析显示AUC值存在统计学显著差异，表明联合诊断方法比单个标志物更有效。
联合CA125、NSE、NLR、PLR和SIRI可提高OSCC的诊断效率。这种联合方法对早期诊断具有高敏感性和特异性。
