Golubnitschaja Olga
Radiologische Klinik, Medizinische Fakultät, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn.
Klin Monbl Augenheilkd. 2018 Feb;235(2):146-150. doi: 10.1055/s-0044-101164. Epub 2018 Feb 15.
Glaucoma is the second leading cause of blindness, with altogether about 70 million patients registered worldwide. These facts prompt us to reconsider currently applied concepts in overall glaucoma management. Innovative strategies of predictive, preventive and personalised medicine (PPPM) are expected to considerably improve disease prevention and personalised treatment. The comprehensive PPPM measures include the application of individualised patient profiles, "phenotyping", molecular characterisation of the pre-lesions and disease stages, innovative screening programs, patient stratification, early and predictive diagnosis, targeted prevention, and the creation of personalised treatment algorithms. The main stakeholders are glaucoma-dedicated researchers, ophthalmologists, general practitioners, groups at risk, specialised medical units, affected patients and their family members, insurances, policy makers, and the diagnostic and pharmaceutical industries. Potential beneficiaries include these groups as well as society as a whole, due to financial savings in the healthcare expected.
青光眼是导致失明的第二大主要原因,全球登记在册的患者总数约为7000万。这些事实促使我们重新审视目前青光眼整体管理中应用的概念。预测性、预防性和个性化医学(PPPM)的创新策略有望显著改善疾病预防和个性化治疗。全面的PPPM措施包括应用个性化患者档案、“表型分析”、病变前期和疾病阶段的分子特征分析、创新筛查项目、患者分层、早期和预测性诊断、靶向预防以及创建个性化治疗算法。主要利益相关者包括青光眼专项研究人员、眼科医生、全科医生、高危人群、专业医疗单位、受影响患者及其家属、保险公司、政策制定者以及诊断和制药行业。由于预计在医疗保健方面节省资金,潜在受益者包括这些群体以及整个社会。