Kaur Parveer, Chudasama Bhupendra
Laboratory of Nanomedicine, School of Physics and Materials Science, Thapar University, Patiala 147004, India.
J Nanosci Nanotechnol. 2018 Mar 1;18(3):1665-1674. doi: 10.1166/jnn.2018.14240.
Gold nanorods (GNRs) owing to their tunable longitudinal surface plasmon resonance in tissue transparent near infrared region have potential applications (like cancer imaging, surface enhanced Raman spectroscopy, cancer targeting, drug delivery and optical hyperthermia) in nanomedicine. Success of these diagnosis/therapy options depends on the plasmonic properties of gold nanorods, which are influenced by the interaction of GNRs with the colloidal medium. In this article, a systematic study is performed to evaluate the effect of colloidal medium on shelf life and stability of gold GNRs. As-synthesized GNRs are preserved in four aqueous media (deionized water, pluronic F-127, CTAB solution and growth solution) and their stability is investigated by closely monitoring the changes in the plasmonic signatures by UV-Visible spectroscopy and variation in hydrodynamic size by photon correlation spectroscopy for 30 days. As-synthesized GNRs are most stable in deionized water followed by pluronic F-127, CTAB and growth solution. The vast difference in the colloidal stability of GNRs in different media is due to the differences in surface driven unzipping of gold in these aqueous media.
金纳米棒（GNRs）由于其在组织透明近红外区域可调谐的纵向表面等离子体共振，在纳米医学中具有潜在应用（如癌症成像、表面增强拉曼光谱、癌症靶向、药物递送和光热疗法）。这些诊断/治疗选择的成功取决于金纳米棒的等离子体特性，而金纳米棒的等离子体特性受其与胶体介质相互作用的影响。在本文中，进行了一项系统研究，以评估胶体介质对金纳米棒保质期和稳定性的影响。合成后的金纳米棒保存在四种水性介质（去离子水、普朗尼克F-127、十六烷基三甲基溴化铵溶液和生长溶液）中，并通过紫外-可见光谱密切监测等离子体特征的变化以及通过光子相关光谱监测30天内流体动力学尺寸的变化，来研究其稳定性。合成后的金纳米棒在去离子水中最稳定，其次是普朗尼克F-127、十六烷基三甲基溴化铵和生长溶液。金纳米棒在不同介质中胶体稳定性的巨大差异是由于这些水性介质中表面驱动的金解链差异所致。
