Bao Mei-Hua, Zhu Shu-Zhen, Gao Xin-Zheng, Sun Hong-Shuo, Feng Zhong-Ping
Department of Anatomy, Histology and Embryology, Science Research Center, Institute of Neuroscience, Changsha Medical University, Changsha, China; Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; Department of Surgery, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; Department of Surgery, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
J Stroke Cerebrovasc Dis. 2018 Jun;27(6):1599-1608. doi: 10.1016/j.jstrokecerebrovasdis.2018.01.010. Epub 2018 Feb 13.
Ischemic stroke is a multifactorial neurologic injury that causes mortality and disability worldwide. Poststroke depression is the most important neuropsychiatric consequence of stroke. Brain-derived neurotrophic factor is a neurotrophin family member that plays key role in regulating neuron survival and differentiation. Studies found a polymorphism in brain-derived neurotrophic factor gene (rs6265) may associate with the ischemic stroke and poststroke depression risk. However, the results are inconclusive and inconsistent.
In the present meta-analysis, the database PubMed, Embase, Cochrane Central Register of Controlled Trials, CNKI, and Chinese Biomedical Literature Database were searched until July 9, 2017.
Seven studies with 1287 cases and 1032 controls were included for the meta-analysis of ischemic stroke, and five studies with 272 cases and 503 controls were included for poststroke depression. The results indicated that the GG genotype of brain-derived neurotrophic factor is related to a significantly lower risk of ischemic stroke in the homozygous and dominant models (odds ratio = .57 and .80, respectively). No significant relation was found between rs6265 and poststroke depression.
Thus, brain-derived neurotrophic factor rs6265 might be recommended as a predictor of susceptibility of ischemic stroke. However, the results of this meta-analysis should be interpreted with caution because of the heterogeneity between studies and low sample size. Further studies are needed to evaluate the associations between rs6265 and poststroke depression, especially in Caucasians, with large sample size.
缺血性中风是一种多因素导致的神经损伤，在全球范围内都会引起死亡和残疾。中风后抑郁是中风最重要的神经精神后果。脑源性神经营养因子是神经营养因子家族成员，在调节神经元存活和分化中起关键作用。研究发现脑源性神经营养因子基因（rs6265）中的一种多态性可能与缺血性中风及中风后抑郁风险相关。然而，结果尚无定论且不一致。
在本荟萃分析中，检索了PubMed、Embase、Cochrane对照试验中央注册库、中国知网和中国生物医学文献数据库，检索截至2017年7月9日。
纳入七项研究共1287例病例和1032例对照进行缺血性中风的荟萃分析，纳入五项研究共272例病例和503例对照进行中风后抑郁的分析。结果表明，在纯合子和显性模型中，脑源性神经营养因子的GG基因型与缺血性中风风险显著降低相关（优势比分别为0.57和0.80）。未发现rs6265与中风后抑郁之间存在显著关联。
因此，脑源性神经营养因子rs6265可能被推荐作为缺血性中风易感性的预测指标。然而，由于研究之间的异质性和样本量较小，本荟萃分析的结果应谨慎解释。需要进一步研究以评估rs6265与中风后抑郁之间的关联，尤其是在白种人中进行大样本研究。
