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单次静脉或皮下全寄生虫免疫可预防实验性脑疟疾。

Protection from experimental cerebral malaria with a single intravenous or subcutaneous whole-parasite immunization.

机构信息

Centre for Infectious Diseases, Parasitology Unit, Heidelberg University Hospital, Heidelberg, Germany.

MalVa GmbH, Heidelberg, Germany.

出版信息

Sci Rep. 2018 Feb 15;8(1):3085. doi: 10.1038/s41598-018-21551-2.

DOI:10.1038/s41598-018-21551-2
PMID:29449638
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5814423/
Abstract

Cerebral malaria is a life-threatening complication of Plasmodia infection and a major cause of child mortality in Sub-Saharan Africa. We report that protection from experimental cerebral malaria in the rodent model is obtained by a single intravenous or subcutaneous whole-parasite immunization. Whole-parasite immunization with radiation-attenuated sporozoites was equally protective as immunization with non-attenuated sporozoites under chemoprophylaxis. Both immunization regimens delayed the development of blood-stage parasites, but differences in cellular and humoral immune mechanisms were observed. Single-dose whole-parasite vaccination might serve as a relatively simple and feasible immunization approach to prevent life-threatening cerebral malaria.

摘要

脑型疟疾是由疟原虫感染引起的危及生命的并发症，也是撒哈拉以南非洲地区儿童死亡的主要原因。我们报告称，通过单次静脉或皮下给予整个寄生虫免疫，可以预防啮齿动物模型中的实验性脑型疟疾。在化学预防的情况下，用减毒的孢子虫进行全寄生虫免疫与用未减毒的孢子虫免疫同样具有保护作用。两种免疫方案都延迟了血期寄生虫的发育，但观察到细胞和体液免疫机制存在差异。单次全寄生虫疫苗接种可能是一种相对简单可行的免疫方法，可预防危及生命的脑型疟疾。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/563d/5814423/c19deb97510b/41598_2018_21551_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/563d/5814423/97db5b46670a/41598_2018_21551_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/563d/5814423/4cce069dbb56/41598_2018_21551_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/563d/5814423/16257730a9e7/41598_2018_21551_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/563d/5814423/24b4d6519538/41598_2018_21551_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/563d/5814423/f47d43688c93/41598_2018_21551_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/563d/5814423/c19deb97510b/41598_2018_21551_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/563d/5814423/97db5b46670a/41598_2018_21551_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/563d/5814423/4cce069dbb56/41598_2018_21551_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/563d/5814423/16257730a9e7/41598_2018_21551_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/563d/5814423/24b4d6519538/41598_2018_21551_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/563d/5814423/f47d43688c93/41598_2018_21551_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/563d/5814423/c19deb97510b/41598_2018_21551_Fig6_HTML.jpg

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Cell Microbiol. 2018 May;20(5):e12819. doi: 10.1111/cmi.12819. Epub 2018 Jan 18.
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A quantitative brain map of experimental cerebral malaria pathology.实验性脑型疟疾病理学的定量脑图谱。
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Attenuated PfSPZ Vaccine induces strain-transcending T cells and durable protection against heterologous controlled human malaria infection.
疟原虫感染引起的可逆性脑水肿中的血脑屏障细胞间通透性增加。
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BCG Provides Short-Term Protection from Experimental Cerebral Malaria in Mice.卡介苗为小鼠实验性脑型疟疾提供短期保护。
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减毒PfSPZ疫苗可诱导产生跨越毒株的T细胞，并对异源受控人体疟疾感染产生持久保护作用。
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