Han Xuesheng, Parker Tory L
dōTERRA International, LLC, 389 S. 1300 W., Pleasant Grove, UT 84062, USA.
Biochim Open. 2017 Mar 21;4:107-111. doi: 10.1016/j.biopen.2017.03.004. eCollection 2017 Jun.
Lemongrass () essential oil (LEO), which has citral as its main component, has exhibited anti-inflammatory effect in both animal and human cells. In this study, we evaluated the anti-inflammatory activity of a commercially available LEO in pre-inflamed human dermal fibroblasts. We first studied the impact of LEO on 17 protein biomarkers that are critically associated with inflammation and tissue remodeling. LEO significantly inhibited production of the inflammatory biomarkers vascular cell adhesion molecule 1 (VCAM-1), interferon gamma-induced protein 10 (IP-10), interferon-inducible T-cell alpha chemoattractant (I-TAC), and monokine induced by gamma interferon (MIG); decreased levels of the tissue remodeling biomarkers collagen-I and III, epidermal growth factor receptor (EGFR), and plasminogen activator inhibitor (PAI-1); and inhibited the immunomodulatory biomarker macrophage colony-stimulating factor (M-CSF). Furthermore, we studied the impact of LEO on genome-wide gene expression profiles. LEO significantly modulated global gene expression and robustly impacted signaling pathways, many of which are critical for inflammation and tissue remodeling processes. This study provides the first evidence of the anti-inflammatory activity of LEO in human skin cells and indicates that it is a good therapeutic candidate for treating inflammatory conditions of the skin.
柠檬草（）精油（LEO），其主要成分是柠檬醛，在动物和人类细胞中均表现出抗炎作用。在本研究中，我们评估了市售LEO对预先炎症化的人皮肤成纤维细胞的抗炎活性。我们首先研究了LEO对17种与炎症和组织重塑密切相关的蛋白质生物标志物的影响。LEO显著抑制炎症生物标志物血管细胞黏附分子1（VCAM-1）、γ干扰素诱导蛋白10（IP-10）、γ干扰素诱导的T细胞α趋化因子（I-TAC）和γ干扰素诱导的单核因子（MIG）的产生；降低组织重塑生物标志物胶原蛋白-I和III、表皮生长因子受体（EGFR）和纤溶酶原激活物抑制剂（PAI-1）的水平；并抑制免疫调节生物标志物巨噬细胞集落刺激因子（M-CSF）。此外，我们研究了LEO对全基因组基因表达谱的影响。LEO显著调节全局基因表达并强烈影响信号通路，其中许多信号通路对炎症和组织重塑过程至关重要。本研究首次提供了LEO在人皮肤细胞中抗炎活性的证据，并表明它是治疗皮肤炎症性疾病的良好治疗候选物。
